The TREX1 Dinosaur Bites the Brain through the LINE

José Luis García Pérez, Marta E Alarcón-Riquelme

Research output: Contribution to journalReview articlepeer-review


In this issue of Cell Stem Cell, Thomas et al. (2017) define the nature of accumulated ssDNA present in the neuron and astrocyte cytoplasm of TREX1 mutated stem cell-derived organoids. Accumulated ssDNAs are derived from LINE-1 endogenous retroelements, providing new clues as to the development of Aicardi-Goutières syndrome in the neural system.

Original languageEnglish
Pages (from-to)287-288
Number of pages2
JournalCell Stem Cell
Issue number3
Publication statusPublished - 7 Sep 2017


  • Journal Article

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