The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains

Sebastian Maurer-Stroh, Nicholas J Dickens, Luke Hughes-Davies, Tony Kouzarides, Frank Eisenhaber, Chris P Ponting

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

We have identified a family of 'Agenet' domains that are plant-specific homologs of Tudor domains. This finding has been extended, using a combination of sequence- and structure-dependent approaches, to show that the three beta-stranded core regions of Tudor, PWWP, chromatin-binding (Chromo) and MBT domains are homologous because they originate from a common ancestor. In addition, we have revealed pairs of tandem repeats in the fragile X mental retardation protein (FMRP) family that are also members of this Tudor domain 'Royal Family'.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalTrends in biochemical sciences
Issue number2
Publication statusPublished - Feb 2003

Keywords / Materials (for Non-textual outputs)

  • Amino Acid Sequence
  • Animals
  • Arabidopsis
  • Drosophila Proteins
  • Evolution, Molecular
  • Humans
  • Insect Proteins
  • Membrane Transport Proteins
  • Minisatellite Repeats
  • Models, Molecular
  • Molecular Sequence Data
  • Plant Proteins
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • Sequence Homology, Amino Acid


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