The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains

Sebastian Maurer-Stroh; Nicholas J Dickens; Luke Hughes-Davies; Tony Kouzarides; Frank Eisenhaber; Chris P Ponting

doi:10.1016/S0968-0004(03)00004-5

The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains

Sebastian Maurer-Stroh, Nicholas J Dickens, Luke Hughes-Davies, Tony Kouzarides, Frank Eisenhaber, Chris P Ponting

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

We have identified a family of 'Agenet' domains that are plant-specific homologs of Tudor domains. This finding has been extended, using a combination of sequence- and structure-dependent approaches, to show that the three beta-stranded core regions of Tudor, PWWP, chromatin-binding (Chromo) and MBT domains are homologous because they originate from a common ancestor. In addition, we have revealed pairs of tandem repeats in the fragile X mental retardation protein (FMRP) family that are also members of this Tudor domain 'Royal Family'.

Original language	English
Pages (from-to)	69-74
Number of pages	6
Journal	Trends in biochemical sciences
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/S0968-0004(03)00004-5
Publication status	Published - Feb 2003

Keywords

Amino Acid Sequence
Animals
Arabidopsis
Drosophila Proteins
Evolution, Molecular
Humans
Insect Proteins
Membrane Transport Proteins
Minisatellite Repeats
Models, Molecular
Molecular Sequence Data
Plant Proteins
Protein Structure, Secondary
Protein Structure, Tertiary
Sequence Homology, Amino Acid

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10.1016/S0968-0004(03)00004-5

Cite this

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title = "The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains",

abstract = "We have identified a family of 'Agenet' domains that are plant-specific homologs of Tudor domains. This finding has been extended, using a combination of sequence- and structure-dependent approaches, to show that the three beta-stranded core regions of Tudor, PWWP, chromatin-binding (Chromo) and MBT domains are homologous because they originate from a common ancestor. In addition, we have revealed pairs of tandem repeats in the fragile X mental retardation protein (FMRP) family that are also members of this Tudor domain 'Royal Family'.",

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author = "Sebastian Maurer-Stroh and Dickens, {Nicholas J} and Luke Hughes-Davies and Tony Kouzarides and Frank Eisenhaber and Ponting, {Chris P}",

year = "2003",

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doi = "10.1016/S0968-0004(03)00004-5",

language = "English",

volume = "28",

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journal = "Trends in biochemical sciences",

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TY - JOUR

T1 - The Tudor domain 'Royal Family'

T2 - Tudor, plant Agenet, Chromo, PWWP and MBT domains

AU - Maurer-Stroh, Sebastian

AU - Dickens, Nicholas J

AU - Hughes-Davies, Luke

AU - Kouzarides, Tony

AU - Eisenhaber, Frank

AU - Ponting, Chris P

PY - 2003/2

Y1 - 2003/2

N2 - We have identified a family of 'Agenet' domains that are plant-specific homologs of Tudor domains. This finding has been extended, using a combination of sequence- and structure-dependent approaches, to show that the three beta-stranded core regions of Tudor, PWWP, chromatin-binding (Chromo) and MBT domains are homologous because they originate from a common ancestor. In addition, we have revealed pairs of tandem repeats in the fragile X mental retardation protein (FMRP) family that are also members of this Tudor domain 'Royal Family'.

AB - We have identified a family of 'Agenet' domains that are plant-specific homologs of Tudor domains. This finding has been extended, using a combination of sequence- and structure-dependent approaches, to show that the three beta-stranded core regions of Tudor, PWWP, chromatin-binding (Chromo) and MBT domains are homologous because they originate from a common ancestor. In addition, we have revealed pairs of tandem repeats in the fragile X mental retardation protein (FMRP) family that are also members of this Tudor domain 'Royal Family'.

KW - Amino Acid Sequence

KW - Animals

KW - Arabidopsis

KW - Drosophila Proteins

KW - Evolution, Molecular

KW - Humans

KW - Insect Proteins

KW - Membrane Transport Proteins

KW - Minisatellite Repeats

KW - Models, Molecular

KW - Molecular Sequence Data

KW - Plant Proteins

KW - Protein Structure, Secondary

KW - Protein Structure, Tertiary

KW - Sequence Homology, Amino Acid

U2 - 10.1016/S0968-0004(03)00004-5

DO - 10.1016/S0968-0004(03)00004-5

M3 - Article

C2 - 12575993

VL - 28

SP - 69

EP - 74

JO - Trends in biochemical sciences

JF - Trends in biochemical sciences

SN - 0968-0004

IS - 2

ER -

The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains

Abstract

Keywords

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