Abstract
We have identified a family of 'Agenet' domains that are plant-specific homologs of Tudor domains. This finding has been extended, using a combination of sequence- and structure-dependent approaches, to show that the three beta-stranded core regions of Tudor, PWWP, chromatin-binding (Chromo) and MBT domains are homologous because they originate from a common ancestor. In addition, we have revealed pairs of tandem repeats in the fragile X mental retardation protein (FMRP) family that are also members of this Tudor domain 'Royal Family'.
Original language | English |
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Pages (from-to) | 69-74 |
Number of pages | 6 |
Journal | Trends in biochemical sciences |
Volume | 28 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2003 |
Keywords / Materials (for Non-textual outputs)
- Amino Acid Sequence
- Animals
- Arabidopsis
- Drosophila Proteins
- Evolution, Molecular
- Humans
- Insect Proteins
- Membrane Transport Proteins
- Minisatellite Repeats
- Models, Molecular
- Molecular Sequence Data
- Plant Proteins
- Protein Structure, Secondary
- Protein Structure, Tertiary
- Sequence Homology, Amino Acid