The UK Biobank imaging enhancement: Rationale, data collection, management and future directions of a multi-modal imaging study of 100,000 participants

Thomas J. Littlejohns, Jo Holliday, Lorna Gibson, Steve Garratt, Niels Oesingmann, Fidel Alfaro-Almagro, Jimmy Bell, Chris Boultwood, Rory Collins, Megan Conroy, Nicola Crabtree, Nicola Doherty, Alejandro Frangi, Nick Harvey, Paul Leeson, Karla Miller, Stefan Neubauer, Steffen Petersen, Jonathan Sellors, Simon SheardStephen Smith, Catherine Sudlow, Paul M Matthews, Naomi Allen

Research output: Contribution to journalArticlepeer-review

Abstract

UK Biobank is a population-based cohort of half a million participants aged 40–69 years recruited between 2006 and 2010. In 2014, UK Biobank started the world’s largest multimodal imaging study, with the aim of re-inviting 100,000 participants to undergo brain, cardiac and abdominal magnetic resonance imaging, dual-energy X-ray absorptiometry and carotid ultrasound. The combination of large-scale multi-modal imaging with extensive phenotypic and genetic data offers an unprecedented resource for scientists to conduct health-related research. This article provides an in-depth overview of the imaging enhancement, including the data collected, how it is managed and processed, and future directions.
Original languageEnglish
JournalNature Communications
Volume11
Issue number1
DOIs
Publication statusPublished - 26 May 2020

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