The unconventional kinetoplastid kinetochore: From discovery toward functional understanding

Bungo Akiyoshi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The kinetochore is the macromolecular protein complex that drives chromosome segregation in eukaryotes. Its most fundamental function is to connect centromeric DNA to dynamic spindle microtubules. Studies in popular model eukaryotes have shown that centromere protein (CENP)-A is critical for DNA-binding, whereas the Ndc80 complex is essential for microtubule-binding. Given their conservation in diverse eukaryotes, it was widely believed that all eukaryotes would utilize these components to make up a core of the kine-tochore. However, a recent study identified an unconventional type of kinetochore in evolutionarily distant kine-toplastid species, showing that chromosome segregation can be achieved using a distinct set of proteins. Here, I review the discovery of the two kinetochore systems and discuss how their studies contribute to a better understanding of the eukaryotic chromosome segregation machinery.

Original languageEnglish
Pages (from-to)1201-1217
Number of pages17
JournalBiochemical Society Transactions
Issue number5
Publication statusPublished - 19 Oct 2016
Externally publishedYes


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