The uptake and metabolism of amino acids, and their unique role in the biology of pathogenic trypanosomatids

Letícia Marchese; Janaina De Freitas Nascimento; Flávia Silva Damasceno; Frédéric Bringaud; Paul A.M. Michels; Ariel Mariano Silber

doi:10.3390/pathogens7020036

The uptake and metabolism of amino acids, and their unique role in the biology of pathogenic trypanosomatids

Letícia Marchese, Janaina De Freitas Nascimento, Flávia Silva Damasceno, Frédéric Bringaud, Paul A.M. Michels, Ariel Mariano Silber^*

^*Corresponding author for this work

School of Biological Sciences

Research output: Contribution to journal › Review article › peer-review

Abstract

Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cycles each of them faces environments with different physical, chemical, biochemical, and biological characteristics. In this work we review how amino acids are obtained from such environments, how they are metabolized, and how they and some of their intermediate metabolites are used as a survival toolbox to cope with the different conditions in which these parasites should establish the infections in the insects and mammalian hosts.

Original language	English
Article number	36
Number of pages	45
Journal	Pathogens
Volume	7
Issue number	2
DOIs	https://doi.org/10.3390/pathogens7020036
Publication status	Published - 1 Apr 2018

Keywords / Materials (for Non-textual outputs)

Amino acid metabolism
Amino acid uptake
Autophagy
Bioenergetics
Host-parasite interaction
Stress management

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10.3390/pathogens7020036

pathogens-07-00036Final published version, 2.06 MB

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title = "The uptake and metabolism of amino acids, and their unique role in the biology of pathogenic trypanosomatids",

abstract = "Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cycles each of them faces environments with different physical, chemical, biochemical, and biological characteristics. In this work we review how amino acids are obtained from such environments, how they are metabolized, and how they and some of their intermediate metabolites are used as a survival toolbox to cope with the different conditions in which these parasites should establish the infections in the insects and mammalian hosts.",

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AU - Marchese, Letícia

AU - Nascimento, Janaina De Freitas

AU - Damasceno, Flávia Silva

AU - Bringaud, Frédéric

AU - Michels, Paul A.M.

AU - Silber, Ariel Mariano

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N2 - Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cycles each of them faces environments with different physical, chemical, biochemical, and biological characteristics. In this work we review how amino acids are obtained from such environments, how they are metabolized, and how they and some of their intermediate metabolites are used as a survival toolbox to cope with the different conditions in which these parasites should establish the infections in the insects and mammalian hosts.

AB - Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cycles each of them faces environments with different physical, chemical, biochemical, and biological characteristics. In this work we review how amino acids are obtained from such environments, how they are metabolized, and how they and some of their intermediate metabolites are used as a survival toolbox to cope with the different conditions in which these parasites should establish the infections in the insects and mammalian hosts.

KW - Amino acid metabolism

KW - Amino acid uptake

KW - Autophagy

KW - Bioenergetics

KW - Host-parasite interaction

KW - Stress management

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DO - 10.3390/pathogens7020036

M3 - Review article

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ER -

The uptake and metabolism of amino acids, and their unique role in the biology of pathogenic trypanosomatids

Abstract

Keywords / Materials (for Non-textual outputs)

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