The use of automated quantitative analysis to evaluate epithelial-to-mesenchymal transition associated proteins in clear cell renal cell carcinoma

Fiach C O'Mahony; Dana Faratian; James Varley; Jyoti Nanda; Marianna Theodoulou; Antony C P Riddick; David J Harrison; Grant D Stewart

doi:10.1371/journal.pone.0031557

The use of automated quantitative analysis to evaluate epithelial-to-mesenchymal transition associated proteins in clear cell renal cell carcinoma

Fiach C O'Mahony, Dana Faratian, James Varley, Jyoti Nanda, Marianna Theodoulou, Antony C P Riddick, David J Harrison, Grant D Stewart

Research output: Contribution to journal › Article › peer-review

Abstract

Epithelial-to-mesenchymal transition (EMT) has recently been implicated in the initiation and progression of renal cell carcinoma (RCC). Some mRNA gene expression studies have suggested a link between the EMT phenotype and poorer clinical outcome from RCC. This study evaluated expression of EMT-associated proteins in RCC using in situ automated quantitative analysis immunofluorescence (AQUA) and compared expression levels with clinical outcome.

Original language	English
Pages (from-to)	e31557
Journal	PLoS ONE
Volume	7
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0031557
Publication status	Published - 2012

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10.1371/journal.pone.0031557

The use of automated quantitative analysis to evaluate epithelial-to-mesenchymal transition associated proteins in clear cell renal cell carcinoma
Copyright: © 2012 O'Mahony et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0031557

Cite this

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title = "The use of automated quantitative analysis to evaluate epithelial-to-mesenchymal transition associated proteins in clear cell renal cell carcinoma",

abstract = "Epithelial-to-mesenchymal transition (EMT) has recently been implicated in the initiation and progression of renal cell carcinoma (RCC). Some mRNA gene expression studies have suggested a link between the EMT phenotype and poorer clinical outcome from RCC. This study evaluated expression of EMT-associated proteins in RCC using in situ automated quantitative analysis immunofluorescence (AQUA) and compared expression levels with clinical outcome.",

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AU - Theodoulou, Marianna

AU - Riddick, Antony C P

AU - Harrison, David J

AU - Stewart, Grant D

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AB - Epithelial-to-mesenchymal transition (EMT) has recently been implicated in the initiation and progression of renal cell carcinoma (RCC). Some mRNA gene expression studies have suggested a link between the EMT phenotype and poorer clinical outcome from RCC. This study evaluated expression of EMT-associated proteins in RCC using in situ automated quantitative analysis immunofluorescence (AQUA) and compared expression levels with clinical outcome.

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The use of automated quantitative analysis to evaluate epithelial-to-mesenchymal transition associated proteins in clear cell renal cell carcinoma

Abstract

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