The utility of combined urine dipstick analysis and specific gravity measurement to determine feline proteinuria

Jorge Perez Accino Salgado, Luis Feo Bernabé , Edgar García Manzanilla , J. Puig

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Objectives: The main objective of this study was to assess the utility of urine dipstick strips for the detection of feline proteinuria when used in combination with the urine specific gravity (USG), with the urine protein-to-creatinine ratio (UPC) as the gold standard method.
Methods: Clinical records were evaluated retrospectively for comprehensive urine analysis, which had been obtained from cats presented to a referral hospital. Diagnostic agreement and test accuracy were calculated for the dipstick test alone and in combination with the USG; using different cut off values for proteinuria. Receiver-operating characteristic (ROC) curves were also calculated.
Results: A total of 121 urine samples were included. The diagnostic agreement between dipstick and UPC was poor. A dipstick result of equal or greater than Trace (0.1 - 0.3 g/l) had a sensitivity of 81% and a specificity of 31% to detect proteinuria. Grouping the samples by USG did not increase the dipstick’s agreement with the UPC and only resulted in a slight improvement in the accuracy of detecting proteinuria.
Clinical significance: The dipstick test was not accurate for detecting proteinuria when combined with the USG in cats. Clinicians should not rely on this test and, regardless of the urine concentration, other appropriate quantitative methods such as UPC should always be performed to detect proteinuria in cats.
Original languageEnglish
JournalJournal of Small Animal Practice
Early online date21 Jul 2020
DOIs
Publication statusE-pub ahead of print - 21 Jul 2020

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