The Utility of the Addenbrooke's Cognitive Examination Version Three in Early-Onset Dementia

Marwa Elamin, Guy Holloway, Thomas H Bak, Suvankar Pal

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

BACKGROUND/AIMS: Early-onset dementia (EOD) is defined as functionally relevant cognitive decline with age of onset at less than 65 years. The aim of this study was to investigate the utility of the recently validated third version of the Addenbrooke's Cognitive Examination (ACE-III) in predicting dementia diagnoses in EOD.

METHODS: ACE-III scores of EOD patients were compared to those of healthy controls (HC) and individuals with subjective memory impairment (SMI).

RESULTS: The study included 71 EOD patients (Alzheimer's disease, n = 31; primary progressive aphasia, n = 11; behavioural-variant frontotemporal dementia, n = 18, and posterior cortical atrophy, n = 11); there were 28 HC and 15 individuals with SMI. At a cut-off score of 88/100, the ACE-III displayed high sensitivity and specificity in distinguishing EOD from HC (91.5 and 96.4%) and SMI (91.5 and 86.7%).

CONCLUSIONS: The ACE-III is a reliable cognitive screening tool in EOD.

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
Issue number1-2
Early online date17 Jan 2015
Publication statusPublished - 2015

Keywords / Materials (for Non-textual outputs)

  • early-onset dementia
  • cognitive assessment
  • early-onset Alzheimer’s disease
  • frontotemporal dementia
  • primary progressive aphasia
  • posterior cortical atrophy
  • Non-Alzheimer dementia
  • Subjective memory complaints
  • Screening for cognitive impairment


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