The value of immunohistochemical expression of BAX in formulating a prognosis for canine cutaneous mast cell tumours

R De F Strefezzi, S R Kleeb, J G Xavier, H Fukumasu, J L Catão-Dias

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Immunohistochemical expression of BAX was evaluated in 24 canine cutaneous mast cell tumours in order to verify the relationship of this expression to the histopathological grade of the lesions and its prognostic value for clinical outcome. BAX expression increased with higher histopathological grades (P=0.0148; P<0.05 between grades I and III). Animals with high levels of BAX expression were 4.25 times more likely to die from the disease and had shorter post-surgical survival times (P=0.0009). These results suggest that alterations in BAX expression may be related to the aggressiveness of canine cutaneous mast cell tumours, indicating that immunohistochemical detection of BAX may be predictive of clinical outcome.

Original languageEnglish
Pages (from-to)314-9
Number of pages6
JournalJournal of Comparative Pathology
Volume146
Issue number4
DOIs
Publication statusPublished - May 2012
Externally publishedYes

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Biomarkers, Tumor/metabolism
  • Brazil/epidemiology
  • Dog Diseases/diagnosis
  • Dogs
  • Female
  • Male
  • Mast Cells/metabolism
  • Mastocytosis, Cutaneous/diagnosis
  • Neoplasm Staging
  • Prognosis
  • Skin Neoplasms/diagnosis
  • Survival Rate
  • bcl-2-Associated X Protein/metabolism

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