The value of immunohistochemical expression of BAX in formulating a prognosis for canine cutaneous mast cell tumours

R De F Strefezzi; S R Kleeb; J G Xavier; H Fukumasu; J L Catão-Dias

doi:10.1016/j.jcpa.2011.07.005

The value of immunohistochemical expression of BAX in formulating a prognosis for canine cutaneous mast cell tumours

R De F Strefezzi, S R Kleeb, J G Xavier, H Fukumasu, J L Catão-Dias

Research output: Contribution to journal › Article › peer-review

Abstract

Immunohistochemical expression of BAX was evaluated in 24 canine cutaneous mast cell tumours in order to verify the relationship of this expression to the histopathological grade of the lesions and its prognostic value for clinical outcome. BAX expression increased with higher histopathological grades (P=0.0148; P<0.05 between grades I and III). Animals with high levels of BAX expression were 4.25 times more likely to die from the disease and had shorter post-surgical survival times (P=0.0009). These results suggest that alterations in BAX expression may be related to the aggressiveness of canine cutaneous mast cell tumours, indicating that immunohistochemical detection of BAX may be predictive of clinical outcome.

Original language	English
Pages (from-to)	314-9
Number of pages	6
Journal	Journal of Comparative Pathology
Volume	146
Issue number	4
DOIs	https://doi.org/10.1016/j.jcpa.2011.07.005
Publication status	Published - May 2012
Externally published	Yes

Keywords / Materials (for Non-textual outputs)

Animals
Biomarkers, Tumor/metabolism
Brazil/epidemiology
Dog Diseases/diagnosis
Dogs
Female
Male
Mast Cells/metabolism
Mastocytosis, Cutaneous/diagnosis
Neoplasm Staging
Prognosis
Skin Neoplasms/diagnosis
Survival Rate
bcl-2-Associated X Protein/metabolism

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10.1016/j.jcpa.2011.07.005

Cite this

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title = "The value of immunohistochemical expression of BAX in formulating a prognosis for canine cutaneous mast cell tumours",

abstract = "Immunohistochemical expression of BAX was evaluated in 24 canine cutaneous mast cell tumours in order to verify the relationship of this expression to the histopathological grade of the lesions and its prognostic value for clinical outcome. BAX expression increased with higher histopathological grades (P=0.0148; P<0.05 between grades I and III). Animals with high levels of BAX expression were 4.25 times more likely to die from the disease and had shorter post-surgical survival times (P=0.0009). These results suggest that alterations in BAX expression may be related to the aggressiveness of canine cutaneous mast cell tumours, indicating that immunohistochemical detection of BAX may be predictive of clinical outcome.",

keywords = "Animals, Biomarkers, Tumor/metabolism, Brazil/epidemiology, Dog Diseases/diagnosis, Dogs, Female, Male, Mast Cells/metabolism, Mastocytosis, Cutaneous/diagnosis, Neoplasm Staging, Prognosis, Skin Neoplasms/diagnosis, Survival Rate, bcl-2-Associated X Protein/metabolism",

author = "Strefezzi, {R De F} and Kleeb, {S R} and Xavier, {J G} and H Fukumasu and Cat{\~a}o-Dias, {J L}",

year = "2012",

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doi = "10.1016/j.jcpa.2011.07.005",

language = "English",

volume = "146",

pages = "314--9",

journal = "Journal of Comparative Pathology",

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AU - Strefezzi, R De F

AU - Kleeb, S R

AU - Xavier, J G

AU - Fukumasu, H

AU - Catão-Dias, J L

PY - 2012/5

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AB - Immunohistochemical expression of BAX was evaluated in 24 canine cutaneous mast cell tumours in order to verify the relationship of this expression to the histopathological grade of the lesions and its prognostic value for clinical outcome. BAX expression increased with higher histopathological grades (P=0.0148; P<0.05 between grades I and III). Animals with high levels of BAX expression were 4.25 times more likely to die from the disease and had shorter post-surgical survival times (P=0.0009). These results suggest that alterations in BAX expression may be related to the aggressiveness of canine cutaneous mast cell tumours, indicating that immunohistochemical detection of BAX may be predictive of clinical outcome.

KW - Animals

KW - Biomarkers, Tumor/metabolism

KW - Brazil/epidemiology

KW - Dog Diseases/diagnosis

KW - Dogs

KW - Female

KW - Male

KW - Mast Cells/metabolism

KW - Mastocytosis, Cutaneous/diagnosis

KW - Neoplasm Staging

KW - Prognosis

KW - Skin Neoplasms/diagnosis

KW - Survival Rate

KW - bcl-2-Associated X Protein/metabolism

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DO - 10.1016/j.jcpa.2011.07.005

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JO - Journal of Comparative Pathology

JF - Journal of Comparative Pathology

IS - 4

ER -

The value of immunohistochemical expression of BAX in formulating a prognosis for canine cutaneous mast cell tumours

Abstract

Keywords / Materials (for Non-textual outputs)

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