The vertebrate muscle-specific RING finger protein family includes MuRF4--a novel, conserved E3-ubiquitin ligase

Daniel J Macqueen, Eduardo N Fuentes, Juan Antonio Valdés, Alfredo Molina, Samuel A M Martin

Research output: Contribution to journalArticlepeer-review

Abstract

Muscle-specific RING finger (MuRF) proteins are E3-ubiquitin ligases and key regulators of muscle growth and turnover. Here, using a range of phylogenomic approaches, we established the complete-definitive MuRF family of vertebrates. Adding to recognized MuRF1, 2 and 3, we describe a novel family member, hereafter MuRF4, which was independently lost during placental mammal and bird evolution, but is otherwise conserved. MuRF4 transcripts were expressed in heart and skeletal muscles of zebrafish, but were barely detectable in striated muscles of adult anole lizards. We also demonstrate that MuRF1 underwent retrotransposition in the teleost fish ancestor, before the retrogene fully replaced the original gene and muscle-specific function.

Original languageEnglish
Pages (from-to)4390-7
Number of pages8
JournalFEBS Letters
Volume588
Issue number23
DOIs
Publication statusPublished - 28 Nov 2014

Keywords

  • Amino Acid Sequence
  • Animals
  • Conserved Sequence
  • Evolution, Molecular
  • Gene Duplication
  • Gene Expression Regulation, Enzymologic
  • Genomics
  • Humans
  • Molecular Sequence Data
  • Phylogeny
  • RING Finger Domains
  • Ubiquitin-Protein Ligases/chemistry
  • Vertebrates/genetics

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