The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei

A J Harmar, H M Marston, S B Shen, C Spratt, K M West, W J Sheward, C F Morrison, J R Dorin, H D Piggins, J C Reubi, J S Kelly, E S Maywood, M H Hastings

Research output: Contribution to journalArticlepeer-review

Abstract

The neuropeptides pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are implicated in the photic entrainment of circadian rhythms in the suprachiasmatic nuclei (SON). We now report that mice carrying a null mutation of the VPAC(2) receptor for VIP and PACAP(Vipr2(-/-)) are incapable of sustaining normal circadian rhythms of rest/activity behavior. These mice also fail to exhibit circadian expression of the core clock genes mPer1, mPer2, and mCry1 and the clock-controlled gene arginine vasopressin (AVP) in the SON. Moreover, the mutants fail to show acute induction of mPer1 and mPer2 by nocturnal illumination. This study highlights the role of intercellular neuropeptidergic signaling in maintenance of circadian function within the SCN.

Original languageEnglish
Pages (from-to)497-508
Number of pages12
JournalCell
Volume109
Issue number4
DOIs
Publication statusPublished - 17 May 2002

Fingerprint

Dive into the research topics of 'The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei'. Together they form a unique fingerprint.

Cite this