The Y402H variant of complement factor H is associated with age-related macular degeneration but not with diabetic retinal disease in the Go-DARTS study

A. S F Doney, G. P. Leese, J. Olson, A. D. Morris, C. N A Palmer

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: The Y402H variant of complement factor H (CFH) is associated with risk of age-related macular degeneration (ARMD). In common with ARMD, diabetic retinal disease also appears to involve complement activation. The aim was to investigate the impact of Y402H on both retinal pathologies in patients with Type 2 diabetes (T2DM) undergoing systematic eye screening. Methods: Patients with T2DM (n = 2350) were genotyped for the CFH Y402H variant. The association of genotype with retinal disease was determined in both retrospective and prospective models. Results: The retrospective study demonstrated that the HH genotype was associated with an age-adjusted odds ratio of 7.4 for ARMD (P = 2.9 × 10 -11). In a longitudinal study in the disease-free cohort, the age-adjusted hazard ratio was 2.8 (P = 2.4 × 10 -7). The life-time hazard ratio was 3.4 (P = 2.1 × 10 -16). We found no association of Y402H with development of referable diabetic retinal disease. Conclusion The ARMD-associated Y402H variant in CFH does not appear to be associated with diabetic retinal disease, although complement activation is involved in the pathoaetiology of both conditions.

Original languageEnglish
Pages (from-to)460-465
Number of pages6
JournalDiabetic Medicine
Volume26
Issue number5
DOIs
Publication statusPublished - 1 May 2009

Keywords

  • Age-related macular degeneration
  • Complement factor H
  • Diabetic retinopathy
  • Type 2 diabetes

Fingerprint

Dive into the research topics of 'The Y402H variant of complement factor H is associated with age-related macular degeneration but not with diabetic retinal disease in the Go-DARTS study'. Together they form a unique fingerprint.

Cite this