Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production

Matthew J Peirce; Matthew Brook; Nicholas Morrice; Robert Snelgrove; Shajna Begum; Alessandra Lanfrancotti; Clare Notley; Tracy Hussell; Andrew P Cope; Robin Wait

doi:10.1371/journal.pone.0011465

Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production

Matthew J Peirce, Matthew Brook, Nicholas Morrice, Robert Snelgrove, Shajna Begum, Alessandra Lanfrancotti, Clare Notley, Tracy Hussell, Andrew P Cope, Robin Wait

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Thymocyte expressed molecule involved in selection 1 (Themis1, SwissProt accession number Q8BGW0) is the recently characterised founder member of a novel family of proteins. A second member of this family, Themis2 (Q91YX0), also known as ICB1 (Induced on contact with basement membrane 1), remains unreported at the protein level despite microarray and EST databases reporting Themis2 mRNA expression in B cells and macrophages.

Original language	English
Pages (from-to)	e11465
Journal	PLoS ONE
Volume	5
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0011465
Publication status	Published - 2010

Keywords / Materials (for Non-textual outputs)

Animals
Cell Line
Cytokines
Enzyme-Linked Immunosorbent Assay
GRB2 Adaptor Protein
Immunoprecipitation
Intracellular Signaling Peptides and Proteins
Lipopolysaccharides
Mice
Mice, Inbred C57BL
Protein Binding
Proteins
Proto-Oncogene Proteins c-vav
RNA Interference
Signal Transduction
Tandem Mass Spectrometry
Toll-Like Receptor 4
Toll-Like Receptors
Tumor Necrosis Factor-alpha

Access to Document

10.1371/journal.pone.0011465

Themis2 ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production
Copyright: © 2010 Peirce et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Final published version, 497 KBLicence: Creative Commons: Attribution (CC-BY)

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011465

Cite this

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title = "Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production",

abstract = "Thymocyte expressed molecule involved in selection 1 (Themis1, SwissProt accession number Q8BGW0) is the recently characterised founder member of a novel family of proteins. A second member of this family, Themis2 (Q91YX0), also known as ICB1 (Induced on contact with basement membrane 1), remains unreported at the protein level despite microarray and EST databases reporting Themis2 mRNA expression in B cells and macrophages.",

keywords = "Animals, Cell Line, Cytokines, Enzyme-Linked Immunosorbent Assay, GRB2 Adaptor Protein, Immunoprecipitation, Intracellular Signaling Peptides and Proteins, Lipopolysaccharides, Mice, Mice, Inbred C57BL, Protein Binding, Proteins, Proto-Oncogene Proteins c-vav, RNA Interference, Signal Transduction, Tandem Mass Spectrometry, Toll-Like Receptor 4, Toll-Like Receptors, Tumor Necrosis Factor-alpha",

author = "Peirce, {Matthew J} and Matthew Brook and Nicholas Morrice and Robert Snelgrove and Shajna Begum and Alessandra Lanfrancotti and Clare Notley and Tracy Hussell and Cope, {Andrew P} and Robin Wait",

year = "2010",

doi = "10.1371/journal.pone.0011465",

language = "English",

volume = "5",

pages = "e11465",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "7",

}

TY - JOUR

T1 - Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production

AU - Peirce, Matthew J

AU - Brook, Matthew

AU - Morrice, Nicholas

AU - Snelgrove, Robert

AU - Begum, Shajna

AU - Lanfrancotti, Alessandra

AU - Notley, Clare

AU - Hussell, Tracy

AU - Cope, Andrew P

AU - Wait, Robin

PY - 2010

Y1 - 2010

N2 - Thymocyte expressed molecule involved in selection 1 (Themis1, SwissProt accession number Q8BGW0) is the recently characterised founder member of a novel family of proteins. A second member of this family, Themis2 (Q91YX0), also known as ICB1 (Induced on contact with basement membrane 1), remains unreported at the protein level despite microarray and EST databases reporting Themis2 mRNA expression in B cells and macrophages.

AB - Thymocyte expressed molecule involved in selection 1 (Themis1, SwissProt accession number Q8BGW0) is the recently characterised founder member of a novel family of proteins. A second member of this family, Themis2 (Q91YX0), also known as ICB1 (Induced on contact with basement membrane 1), remains unreported at the protein level despite microarray and EST databases reporting Themis2 mRNA expression in B cells and macrophages.

KW - Animals

KW - Cell Line

KW - Cytokines

KW - Enzyme-Linked Immunosorbent Assay

KW - GRB2 Adaptor Protein

KW - Immunoprecipitation

KW - Intracellular Signaling Peptides and Proteins

KW - Lipopolysaccharides

KW - Mice

KW - Mice, Inbred C57BL

KW - Protein Binding

KW - Proteins

KW - Proto-Oncogene Proteins c-vav

KW - RNA Interference

KW - Signal Transduction

KW - Tandem Mass Spectrometry

KW - Toll-Like Receptor 4

KW - Toll-Like Receptors

KW - Tumor Necrosis Factor-alpha

U2 - 10.1371/journal.pone.0011465

DO - 10.1371/journal.pone.0011465

M3 - Article

C2 - 20644716

SN - 1932-6203

VL - 5

SP - e11465

JO - PLoS ONE

JF - PLoS ONE

IS - 7

ER -

Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

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