Abstract
Heart failure is a systemic disorder characterised by tissue hypoxia and secondary organ dysfunction which occurs in response to various myocardial insults that include ischaemia, viral infections, and toxins. In addition to maladaptive neurohumoral activation, heart failure is associated with an inflammatory state that appears to have a detrimental effect on cardiac function and prognosis. This has led to the suggestion that anti-inflammatory interventions may have therapeutic potential in the symptomatic and prognostic treatment of patients with heart failure. This review considers the role of inhibition of the cytokine tumour necrosis factor alpha in the treatment of heart failure.
| Original language | English |
|---|---|
| Pages (from-to) | 14-8 |
| Number of pages | 5 |
| Journal | Heart |
| Volume | 89 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2003 |
Keywords / Materials (for Non-textual outputs)
- Animals
- Apoptosis
- Cardiac Output, Low
- Chronic Disease
- Forecasting
- Humans
- Models, Animal
- Myocardial Contraction
- Myocytes, Cardiac
- Nitric Oxide
- Oxidative Stress
- Randomized Controlled Trials as Topic
- Receptors, Tumor Necrosis Factor
- Tumor Necrosis Factor-alpha