Therapeutic molecular targets in human chondrosarcoma

Nuor Jamil, Sarah Howie, Donald M. Salter

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

P>Chondrosarcomas are malignant cartilage tumours. They are poorly responsive to chemotherapy and radiotherapy. Treatment is usually limited to surgical resection; however, survival of patients with high-grade chondrosarcoma is poor, even with wide surgical resection. Induction of apoptosis in chondrosarcoma cells, either directly or by enhancement of the response to chemotherapeutic drugs and radiation, may be a route by which outcome can be improved. In this article, we review potential molecular targets that regulate chondrocyte apoptosis and discuss the experimental evidence for their utility.

Original languageEnglish
Pages (from-to)387-393
Number of pages7
JournalInternational Journal of Experimental Pathology
Volume91
Issue number5
DOIs
Publication statusPublished - Oct 2010

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