Therapeutic potential of chemokine signal inhibition for metastatic breast cancer

Takanori Kitamura; Jeffrey W Pollard

doi:10.1016/j.phrs.2015.08.004

Therapeutic potential of chemokine signal inhibition for metastatic breast cancer

Takanori Kitamura, Jeffrey W Pollard

School of Regeneration and Repair

Research output: Contribution to journal › Article › peer-review

Abstract

Metastatic breast cancer is incurable by current therapies including chemotherapy and immunotherapy. Accumulating evidence indicates that tumor-infiltrating macrophages promote establishment of the lethal metastatic foci and contribute to therapeutic resistance. Recent studies suggest that the accumulation of these macrophages is regulated by a chemokine network established in the tumor microenvironment. In this perspective paper, we elaborate on the chemokine signals that can attract monocytes/macrophages to the site of metastasis, and discuss whether inhibition of these chemokine signals can represent a new therapeutic strategy for metastatic breast cancer.

Original language	English
Journal	Pharmacological Research
Early online date	11 Aug 2015
DOIs	https://doi.org/10.1016/j.phrs.2015.08.004
Publication status	Published - Oct 2015

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10.1016/j.phrs.2015.08.004

Therapeutic potential of chemokine signal inhibition for metastatic breast cancer
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Chancellors fellowship – Takanori Kitamura (G37048)
Kitamura, T. (Principal Investigator)
31/07/12 → …
Project: University Awarded Project Funding
The metastatic cascade: macrophages lead the way
Pollard, J. (Principal Investigator)
UK-based charities
1/10/13 → 30/06/21
Project: Research
Integrated Multi-Dimensional Molecular Organ Imaging
Wiegand, R. (Principal Investigator) & Pollard, J. (Co-investigator)
MRC
1/02/13 → 31/01/16
Project: Research

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title = "Therapeutic potential of chemokine signal inhibition for metastatic breast cancer",

abstract = "Metastatic breast cancer is incurable by current therapies including chemotherapy and immunotherapy. Accumulating evidence indicates that tumor-infiltrating macrophages promote establishment of the lethal metastatic foci and contribute to therapeutic resistance. Recent studies suggest that the accumulation of these macrophages is regulated by a chemokine network established in the tumor microenvironment. In this perspective paper, we elaborate on the chemokine signals that can attract monocytes/macrophages to the site of metastasis, and discuss whether inhibition of these chemokine signals can represent a new therapeutic strategy for metastatic breast cancer.",

author = "Takanori Kitamura and Pollard, \{Jeffrey W\}",

year = "2015",

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AU - Pollard, Jeffrey W

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N2 - Metastatic breast cancer is incurable by current therapies including chemotherapy and immunotherapy. Accumulating evidence indicates that tumor-infiltrating macrophages promote establishment of the lethal metastatic foci and contribute to therapeutic resistance. Recent studies suggest that the accumulation of these macrophages is regulated by a chemokine network established in the tumor microenvironment. In this perspective paper, we elaborate on the chemokine signals that can attract monocytes/macrophages to the site of metastasis, and discuss whether inhibition of these chemokine signals can represent a new therapeutic strategy for metastatic breast cancer.

AB - Metastatic breast cancer is incurable by current therapies including chemotherapy and immunotherapy. Accumulating evidence indicates that tumor-infiltrating macrophages promote establishment of the lethal metastatic foci and contribute to therapeutic resistance. Recent studies suggest that the accumulation of these macrophages is regulated by a chemokine network established in the tumor microenvironment. In this perspective paper, we elaborate on the chemokine signals that can attract monocytes/macrophages to the site of metastasis, and discuss whether inhibition of these chemokine signals can represent a new therapeutic strategy for metastatic breast cancer.

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DO - 10.1016/j.phrs.2015.08.004

M3 - Article

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SN - 1043-6618

JO - Pharmacological Research

JF - Pharmacological Research

ER -

Therapeutic potential of chemokine signal inhibition for metastatic breast cancer

Abstract

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Projects

Chancellors fellowship – Takanori Kitamura (G37048)

The metastatic cascade: macrophages lead the way

Integrated Multi-Dimensional Molecular Organ Imaging

Cite this