Therapeutic targets in inflammatory disease

David A Hume; David P Fairlie

doi:10.2174/092986705774462923

Therapeutic targets in inflammatory disease

David A Hume, David P Fairlie

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

This commentary is an introduction to a special issue on "Latest Developments in the Treatment of Inflammation". It outlines some key events in the inflammatory response to infection or injury and describes some of the important drug targets of relevance to the succeeding articles, which survey inhibitors of these targets as prospective or current antiinflammatory drugs. It also highlights important limitations in the validation of inflammatory drug targets, and in the rate of discovery and development of new antiinflammatory drugs.

Original language	English
Pages (from-to)	2925-9
Number of pages	5
Journal	Current Medicinal Chemistry
Volume	12
Issue number	25
DOIs	https://doi.org/10.2174/092986705774462923
Publication status	Published - 2005

Keywords / Materials (for Non-textual outputs)

Anti-Inflammatory Agents
Enzyme Inhibitors
Humans
Inflammation
Models, Immunological
NF-kappa B
Peroxisome Proliferator-Activated Receptors
Phospholipases A
Receptors, G-Protein-Coupled
Structure-Activity Relationship
p38 Mitogen-Activated Protein Kinases

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10.2174/092986705774462923

http://www.eurekaselect.com/60136/article

Cite this

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title = "Therapeutic targets in inflammatory disease",

abstract = "This commentary is an introduction to a special issue on {"}Latest Developments in the Treatment of Inflammation{"}. It outlines some key events in the inflammatory response to infection or injury and describes some of the important drug targets of relevance to the succeeding articles, which survey inhibitors of these targets as prospective or current antiinflammatory drugs. It also highlights important limitations in the validation of inflammatory drug targets, and in the rate of discovery and development of new antiinflammatory drugs.",

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author = "Hume, {David A} and Fairlie, {David P}",

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language = "English",

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journal = "Current Medicinal Chemistry",

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AU - Fairlie, David P

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AB - This commentary is an introduction to a special issue on "Latest Developments in the Treatment of Inflammation". It outlines some key events in the inflammatory response to infection or injury and describes some of the important drug targets of relevance to the succeeding articles, which survey inhibitors of these targets as prospective or current antiinflammatory drugs. It also highlights important limitations in the validation of inflammatory drug targets, and in the rate of discovery and development of new antiinflammatory drugs.

KW - Anti-Inflammatory Agents

KW - Enzyme Inhibitors

KW - Humans

KW - Inflammation

KW - Models, Immunological

KW - NF-kappa B

KW - Peroxisome Proliferator-Activated Receptors

KW - Phospholipases A

KW - Receptors, G-Protein-Coupled

KW - Structure-Activity Relationship

KW - p38 Mitogen-Activated Protein Kinases

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DO - 10.2174/092986705774462923

M3 - Article

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SN - 0929-8673

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SP - 2925

EP - 2929

JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

IS - 25

ER -

Therapeutic targets in inflammatory disease

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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