Abstract
Cytosolic thioredoxin reductase (TR) is an FAD-containing homodimeric selenoenzyme which, together with thioredoxin (Trx) and NADPH, forms a powerful oxidoreductase system. Cytoplasmic glutathione peroxidase (GPX-1) is a selenoprotein with antioxidant activity. The TR/Trx system has been associated with cellular processes including regulation of cell growth, and modification of activity of transcription factors. TR may also act as an antioxidant. We have measured TR activity, TR concentration, and GPX-1 activity in human hepatic cytosols from foetuses and neonates. The concentration of TR was significantly greater (P
| Original language | English |
|---|---|
| Pages (from-to) | 237-41 |
| Number of pages | 5 |
| Journal | BBA - Biomembranes |
| Volume | 1526 |
| Issue number | 3 |
| Publication status | Published - 2001 |