Abstract
We describe a tool, THoR, that automatically creates and curates multiple sequence alignments representing protein domains. This exploits both PSI-BLAST and HMMER algorithms and provides an accurate and comprehensive alignment for any domain family. The entire process is designed for use via a web-browser, with simple links and cross-references to relevant information, to assist the assessment of biological significance. THoR has been benchmarked for accuracy using the SMART and pufferfish genome databases.
Original language | English |
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Pages (from-to) | R52 |
Journal | Genome Biology |
Volume | 4 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2003 |
Keywords
- Algorithms
- Animals
- Benchmarking
- Databases, Protein
- Fish Proteins
- Genome
- Internet
- Peptides
- Protein Structure, Tertiary
- Sequence Alignment
- Sequence Homology, Amino Acid
- Software
- Tetraodontiformes