THoR: a tool for domain discovery and curation of multiple alignments

Nicholas J Dickens; Chris P Ponting

doi:10.1186/gb-2003-4-8-r52

THoR: a tool for domain discovery and curation of multiple alignments

Nicholas J Dickens, Chris P Ponting

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

We describe a tool, THoR, that automatically creates and curates multiple sequence alignments representing protein domains. This exploits both PSI-BLAST and HMMER algorithms and provides an accurate and comprehensive alignment for any domain family. The entire process is designed for use via a web-browser, with simple links and cross-references to relevant information, to assist the assessment of biological significance. THoR has been benchmarked for accuracy using the SMART and pufferfish genome databases.

Original language	English
Pages (from-to)	R52
Journal	Genome Biology
Volume	4
Issue number	8
DOIs	https://doi.org/10.1186/gb-2003-4-8-r52
Publication status	Published - 2003

Keywords

Algorithms
Animals
Benchmarking
Databases, Protein
Fish Proteins
Genome
Internet
Peptides
Protein Structure, Tertiary
Sequence Alignment
Sequence Homology, Amino Acid
Software
Tetraodontiformes

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10.1186/gb-2003-4-8-r52

Cite this

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abstract = "We describe a tool, THoR, that automatically creates and curates multiple sequence alignments representing protein domains. This exploits both PSI-BLAST and HMMER algorithms and provides an accurate and comprehensive alignment for any domain family. The entire process is designed for use via a web-browser, with simple links and cross-references to relevant information, to assist the assessment of biological significance. THoR has been benchmarked for accuracy using the SMART and pufferfish genome databases.",

keywords = "Algorithms, Animals, Benchmarking, Databases, Protein, Fish Proteins, Genome, Internet, Peptides, Protein Structure, Tertiary, Sequence Alignment, Sequence Homology, Amino Acid, Software, Tetraodontiformes",

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year = "2003",

doi = "10.1186/gb-2003-4-8-r52",

language = "English",

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TY - JOUR

T1 - THoR

T2 - a tool for domain discovery and curation of multiple alignments

AU - Dickens, Nicholas J

AU - Ponting, Chris P

PY - 2003

Y1 - 2003

N2 - We describe a tool, THoR, that automatically creates and curates multiple sequence alignments representing protein domains. This exploits both PSI-BLAST and HMMER algorithms and provides an accurate and comprehensive alignment for any domain family. The entire process is designed for use via a web-browser, with simple links and cross-references to relevant information, to assist the assessment of biological significance. THoR has been benchmarked for accuracy using the SMART and pufferfish genome databases.

AB - We describe a tool, THoR, that automatically creates and curates multiple sequence alignments representing protein domains. This exploits both PSI-BLAST and HMMER algorithms and provides an accurate and comprehensive alignment for any domain family. The entire process is designed for use via a web-browser, with simple links and cross-references to relevant information, to assist the assessment of biological significance. THoR has been benchmarked for accuracy using the SMART and pufferfish genome databases.

KW - Algorithms

KW - Animals

KW - Benchmarking

KW - Databases, Protein

KW - Fish Proteins

KW - Genome

KW - Internet

KW - Peptides

KW - Protein Structure, Tertiary

KW - Sequence Alignment

KW - Sequence Homology, Amino Acid

KW - Software

KW - Tetraodontiformes

U2 - 10.1186/gb-2003-4-8-r52

DO - 10.1186/gb-2003-4-8-r52

M3 - Article

C2 - 12914660

VL - 4

SP - R52

JO - Genome Biology

JF - Genome Biology

SN - 1465-6906

IS - 8

ER -

THoR: a tool for domain discovery and curation of multiple alignments

Abstract

Keywords

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