THoR: a tool for domain discovery and curation of multiple alignments

Nicholas J Dickens, Chris P Ponting

Research output: Contribution to journalArticlepeer-review


We describe a tool, THoR, that automatically creates and curates multiple sequence alignments representing protein domains. This exploits both PSI-BLAST and HMMER algorithms and provides an accurate and comprehensive alignment for any domain family. The entire process is designed for use via a web-browser, with simple links and cross-references to relevant information, to assist the assessment of biological significance. THoR has been benchmarked for accuracy using the SMART and pufferfish genome databases.

Original languageEnglish
Pages (from-to)R52
JournalGenome Biology
Issue number8
Publication statusPublished - 2003


  • Algorithms
  • Animals
  • Benchmarking
  • Databases, Protein
  • Fish Proteins
  • Genome
  • Internet
  • Peptides
  • Protein Structure, Tertiary
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Software
  • Tetraodontiformes


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