TY - JOUR
T1 - Thyroid hormone levels are associated with metabolic components
T2 - A cross-sectional study
AU - Punda, Ante
AU - Škrabić, Veselin
AU - Torlak, Vesela
AU - Gunjača, Ivana
AU - Perica, Vesna Boraska
AU - Kolčić, Ivana
AU - Polašek, Ozren
AU - Hayward, Caroline
AU - Zemunik, Tatijana
AU - Matana, Antonela
N1 - Funding Information:
Funding This work has been supported by the Croatian Science Foundation under the project “Regulation of Thyroid and Parathyroid Function and Blood Calcium Homeostasis” (No. 2593). The “10 001 Dalmatians” project was funded by grants from the Medical Research Council (UK), Euro- pean Commission Framework 6 project EUROSPAN (Contract No. LSHG-CT-2006018947), the Republic of Croatia Ministry of Science, Education and Sports research grant (216-1080315-0302), the Croatian Science Foundation (grant 8875), CEKOM (Ministry of Economy, Entrepreneurship and Crafts), and the Research Centre of Excellence in Personalized Medicine (Ministry of Science and Education). ethical approval given by the Ethics Committee of the University of Split School of Medicine (2181-198-03-04-14-0031). declaration of authorship AP, VŠ, and TZ conceived and designed the study; VT, IG, VBP, IK, OP, CH, and TZ acquired the data; TZ and AM analyzed and interpreted the data; AP, IG, TZ, and AM drafted the manuscript; AP, VŠ, VT, VBP, IK, OP, CH, and TZ critically revised the manuscript for important intellectual content; all authors gave approval of the version to be submitted; all authors agree to be accountable for all aspects of the work. Competing interests OP is a member of the Editorial Bord of the Croatian Medical Journal. To ensure that any possible conflict of interest relevant to the journal has been addressed, this article was reviewed according to best practice guidelines of international editorial organizations. All authors have completed the Unified Competing Interest form at www.icmje.org/coi_disclosure.pdf (available on request from the corresponding author) and declare: no support from any organization for the submitted work; no financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years; no other relationships or activities that could appear to have influenced the submitted work.
Publisher Copyright:
© 2020 Medicinska Naklada Zagreb. All rights reserved.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Aim To analyze the association of thyroid function and hormone levels with metabolic syndrome (MetS) and its components. Methods This cross-sectional population-based study involved 2183 Croatian individuals with no history of thyroid disease, hypertension, diabetes, and hyperlipidemia. MetS was diagnosed according to the National Cholesterol Education Program’s Adult Treatment Panel III criteria. Results We found no association between thyroid function groups and the prevalence of MetS and its components. Clinically hypothyroid participants showed significantly higher triceps skinfold measurements than subclinically hypothyroid and euthyroid participants. Furthermore, clinically hypothyroid participants had higher abdominal skinfold thickness than subclinically hypothyroid participants. Otherwise, suprailiac and abdominal skinfold measurements were higher in the subclinically and clinically hyperthyroid group of participants compared with euthyroid and subclinically hypothyroid participants. A strong positive association of thyroid-stimulating hormone (TSH) and strong negative association of free triiodothyronine (fT3) and free thyroxine (fT4) levels with HOMA-IR and cholesterol levels were found. Furthermore, the fT4 level also showed a strong negative association with HDL and triceps skinfold thickness. Conclusions This study supports the standing that TSH, fT3, and fT4 levels are important variables to determine the association of thyroid function with MetS.
AB - Aim To analyze the association of thyroid function and hormone levels with metabolic syndrome (MetS) and its components. Methods This cross-sectional population-based study involved 2183 Croatian individuals with no history of thyroid disease, hypertension, diabetes, and hyperlipidemia. MetS was diagnosed according to the National Cholesterol Education Program’s Adult Treatment Panel III criteria. Results We found no association between thyroid function groups and the prevalence of MetS and its components. Clinically hypothyroid participants showed significantly higher triceps skinfold measurements than subclinically hypothyroid and euthyroid participants. Furthermore, clinically hypothyroid participants had higher abdominal skinfold thickness than subclinically hypothyroid participants. Otherwise, suprailiac and abdominal skinfold measurements were higher in the subclinically and clinically hyperthyroid group of participants compared with euthyroid and subclinically hypothyroid participants. A strong positive association of thyroid-stimulating hormone (TSH) and strong negative association of free triiodothyronine (fT3) and free thyroxine (fT4) levels with HOMA-IR and cholesterol levels were found. Furthermore, the fT4 level also showed a strong negative association with HDL and triceps skinfold thickness. Conclusions This study supports the standing that TSH, fT3, and fT4 levels are important variables to determine the association of thyroid function with MetS.
UR - http://www.scopus.com/inward/record.url?scp=85087693255&partnerID=8YFLogxK
U2 - 10.3325/cmj.2020.61.230
DO - 10.3325/cmj.2020.61.230
M3 - Article
C2 - 32643339
AN - SCOPUS:85087693255
VL - 61
SP - 230
EP - 238
JO - Croatian Medical Journal
JF - Croatian Medical Journal
SN - 0353-9504
IS - 3
ER -