Thyroid hormones regulate expression of the neural cell adhesion molecule in adult skeletal muscle

Joanne Thompson, S E Moore, F S Walsh

Research output: Contribution to journalArticlepeer-review

Abstract

Adult rat skeletal muscle does not express detectable levels of neural cell adhesion molecule (N-CAM) and membrane activity mediated by nerve appears to repress the N-CAM gene. N-CAM expression in skeletal muscle can however be reinduced by hypothyroidism. Thyroidectomised rats re-express N-CAM mRNAs of 5.2 and 2.9 kb and Western blot analysis showed protein bands of 125 and 155 kDa. Immunofluorescence analysis also showed high levels of N-CAM in the sarcolemma. These changes in N-CAM expression could be reversed by treatment of hypothyroid rats with thyroxine. Thus thyroid hormones as well as neural influences appear to control N-CAM expression in skeletal muscle.
Original languageEnglish
Pages (from-to)135-8
Number of pages4
JournalFEBS Letters
Volume219
Issue number1
Publication statusPublished - 1987

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