Tigecycline resistance can occur independently of the ramA gene in Klebsiella pneumoniae

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Tigecycline resistance in Klebsiella pneumoniae results from ramA upregulation that causes the overexpression of the efflux pump, AcrAB-TolC. Tigecycline mutants, derived from Ecl8ΔramA, can exhibit a multidrug resistance phenotype due to increased transcription of the marA, rarA, acrAB, and oqxAB genes. These findings support the idea that tigecycline or multidrug resistance in K. pneumoniae, first, is not solely dependent on the ramA gene, and second, can arise via alternative regulatory pathways in K. pneumoniae.
Original languageEnglish
Pages (from-to)4466
Number of pages4467
JournalAntimicrobial Agents and Chemotherapy
DOIs
Publication statusPublished - 2012

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