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Abstract
Time-resolved Raman and fluorescence lifetime spectroscopy imaging yields new research insights with great potential in applications including biomedical diagnostics, carbon materials, and battery development. Single Photon Avalanche Diode (SPAD) arrays are ideal for such applications and we present to our knowledge the first time-resolved Raman images obtained with such sensors. Utilizing motorized and confocal scanning configurations we obtain near shot-noise limited performance, room temperature operation, millisecond spectral acquisition times, and simultaneous acquisition and discrimination of Raman and fluorescence with high spectral resolution and range. Detailed images and spectra from samples including calcite, diamond, and single-wall carbon nanotubes demonstrate the possibility of high-resolution time-resolved Raman and fluorescence imaging.
Original language | English |
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Title of host publication | Optical Biopsy XXI |
Subtitle of host publication | Toward Real-Time Spectroscopic Imaging and Diagnosis |
Editors | Robert R. Alfano, Angela B. Seddon |
Publisher | SPIE |
ISBN (Electronic) | 9781510658516 |
DOIs | |
Publication status | Published - 2023 |
Event | Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis 2023 - San Francisco, United States Duration: 31 Jan 2023 → 1 Feb 2023 |
Publication series
Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
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Volume | 12373 |
ISSN (Print) | 1605-7422 |
Conference
Conference | Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis 2023 |
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Country/Territory | United States |
City | San Francisco |
Period | 31/01/23 → 1/02/23 |
Keywords / Materials (for Non-textual outputs)
- fluorescence imaging
- fluorescence lifetime imaging.
- Raman imaging
- Single Photon Avalanche Diode
- time-correlated spectroscopy
Fingerprint
Dive into the research topics of 'Time-correlated Raman imaging with a SPAD line sensor'. Together they form a unique fingerprint.Projects
- 1 Finished
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EPSRC IRC Proteus - Multiplexed 'Touch And Tell' Optical Molecular Sensing And Imaging - Lifetime And Beyond
Dhaliwal, K., Haslett, C. & Walsh, T.
1/01/19 → 1/06/23
Project: Research