Time-correlated Raman imaging with a SPAD line sensor

Neil Finlayson*, Heather McEwan, Gillian E. Brown, Alistair Gorman, Andrey Gromov, Colin J. Campbell, Ahmet Erdogan, Robert K. Henderson, Gareth O.S. Williams

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract / Description of output

Time-resolved Raman and fluorescence lifetime spectroscopy imaging yields new research insights with great potential in applications including biomedical diagnostics, carbon materials, and battery development. Single Photon Avalanche Diode (SPAD) arrays are ideal for such applications and we present to our knowledge the first time-resolved Raman images obtained with such sensors. Utilizing motorized and confocal scanning configurations we obtain near shot-noise limited performance, room temperature operation, millisecond spectral acquisition times, and simultaneous acquisition and discrimination of Raman and fluorescence with high spectral resolution and range. Detailed images and spectra from samples including calcite, diamond, and single-wall carbon nanotubes demonstrate the possibility of high-resolution time-resolved Raman and fluorescence imaging.

Original languageEnglish
Title of host publicationOptical Biopsy XXI
Subtitle of host publicationToward Real-Time Spectroscopic Imaging and Diagnosis
EditorsRobert R. Alfano, Angela B. Seddon
PublisherSPIE
ISBN (Electronic)9781510658516
DOIs
Publication statusPublished - 2023
EventOptical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis 2023 - San Francisco, United States
Duration: 31 Jan 20231 Feb 2023

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume12373
ISSN (Print)1605-7422

Conference

ConferenceOptical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis 2023
Country/TerritoryUnited States
CitySan Francisco
Period31/01/231/02/23

Keywords / Materials (for Non-textual outputs)

  • fluorescence imaging
  • fluorescence lifetime imaging.
  • Raman imaging
  • Single Photon Avalanche Diode
  • time-correlated spectroscopy

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