Time Multiplexed Active Neural Probe with 1356 Parallel Recording Sites

Bogdan C. Raducanu, Refet F. Yazicioglu, Carolina M. Lopez, Marco Ballini, Jan Putzeys, Shiwei Wang, Alexandru Andrei, Veronique Rochus, Marleen Welkenhuysen, Nick van Helleputte, Silke Musa, Robert Puers, Fabian Kloosterman, Chris van Hoof, Richárd Fiáth, István Ulbert, Srinjoy Mitra

Research output: Contribution to journalArticlepeer-review


We present a high electrode density and high channel count CMOS (complementary metal-oxide-semiconductor) active neural probe containing 1344 neuron sized recording pixels (20 µm × 20 µm) and 12 reference pixels (20 µm × 80 µm), densely packed on a 50 µm thick, 100 µm wide, and 8 mm long shank. The active electrodes or pixels consist of dedicated in-situ circuits for signal source amplification, which are directly located under each electrode. The probe supports the simultaneous recording of all 1356 electrodes with sufficient signal to noise ratio for typical neuroscience applications. For enhanced performance, further noise reduction can be achieved while using half of the electrodes (678). Both of these numbers considerably surpass the state-of-the art active neural probes in both electrode count and number of recording channels. The measured input referred noise in the action potential band is 12.4 µVrms, while using 678 electrodes, with just 3 µW power dissipation per pixel and 45 µW per read-out channel (including data transmission).
Original languageEnglish
Article number2388
Number of pages20
Issue number10
Publication statusPublished - 19 Oct 2017


  • CMOS,active electrode,active neural probes,high density component,neural amplifier,neural array,neural recording


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