Time-resolved Fluorescence Spectroscopy and Imaging in the Proteus Project

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The aim of the interdisciplinary Proteus project is to develop high-speed fluorescence imaging technologies that will provide quick bedside diagnosis and management of lung diseases in the clinical environment. In this poster we will cover some of the key technology advances – fluorescence lifetime spectrometers, confocal imaging systems, fibre imaging bundles and SPAD detector arrays – and present results we have achieved so far, including the development of a 512 pixel TCSPC line sensor with 85 GEvent/s throughput, leading to real-time confocal fluorescence lifetime imaging at 10 fps using an achromatic optical laser scanning microscopy system acquired through a clinical imaging fibre bundle. The system has full spectral range between 500-750nm and fluorescence lifetimes are captured with an adjustable time window of 1.6-204.8ns with a resolution of 50ps.
Original languageEnglish
Title of host publicationAAAS 2019 Annual Meeting
Publication statusPublished - 17 Feb 2019

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