Time to resolution of respiratory and systemic coronavirus disease 2019 symptoms in community setting

Aurélien Dinh, Luc Jaulmes, Agnès Dechartres, Clara Duran, Hélène Mascitti, Xavier Lescure, Youri Yordanov, Patrick Jourdain

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Objectives To assess the time to resolution of respiratory and systemic symptoms and their associated factors in outpatients during the coronavirus disease 2019 (COVID-19) pandemic. Methods Cohort study including adult outpatients, managed with Covidom, a telesurveillance solution, with RT-PCR-confirmed diagnosis, from 9 March 2020 until 23 February 2021. Follow up was 30 days after symptom onset. Results Among the 9667 patients included, mean age was 43.2 ± 14.0 years, and 67.5% were female (n = 6522). Median body mass index (BMI) was 25.0 kg/m2 (interquartile range 22.1–28.8 kg/m2). Main co-morbidities were: hypertension (12.9%; n = 1247), asthma (11.0%; n = 1063) and diabetes mellitus (5.5%; n = 527). The most frequent symptom during follow up was dyspnoea (65.1%; n = 6296), followed by tachypnoea (49.9%; n = 4821), shivers (45.6%; n = 4410) and fever (36.7%; n = 3550). Median times to resolution of systemic and respiratory symptoms were 3 days (95% CI 2−4 days) and 7 days (95% CI 6−8 days), respectively. Ultimately, 17.2% (95% CI 15.7%−18.8%) still presented respiratory symptoms at day 30. Longer time to respiratory symptom resolution was associated with older age, increased BMI, chronic obstructive pulmonary disease, coronary artery disease, asthma and heart failure. Regarding systemic symptoms, coronary artery disease, asthma, age above 40 years and elevated BMI were associated with longer time to resolution. Conclusions Time to symptom resolution among outpatients with COVID-19 seemed shorter for systemic than respiratory symptoms. Prolonged respiratory symptoms were common at day 30. Risk factors associated with later resolution included age, and cardiovascular and pulmonary diseases.
Original languageEnglish
Pages (from-to)1862.e1-1862.e4
Number of pages4
JournalClinical Microbiology and Infection
Issue number12
Early online date3 Sept 2021
Publication statusPublished - 29 Nov 2021

Keywords / Materials (for Non-textual outputs)

  • Community setting
  • Coronavirus disease 2019
  • Dyspnoea
  • Sequelae
  • Symptom duration
  • Telemedicine


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