Tissue-specific differentiation of colonic macrophages requires TGFβ receptor-mediated signaling

A Schridde, C C Bain, J U Mayer, J Montgomery, E Pollet, B Denecke, S W F Milling, S J Jenkins, M Dalod, S Henri, B Malissen, O Pabst, A Mcl Mowat

Research output: Contribution to journalArticlepeer-review

Abstract

Intestinal macrophages (mφ) form one of the largest populations of mφ in the body and are vital for the maintenance of gut homeostasis. They have several unique properties and are derived from local differentiation of classical Ly6Chi monocytes, but the factors driving this tissue-specific process are not understood. Here we have used global transcriptomic analysis to identify a unique homeostatic signature of mature colonic mφ that is acquired as they differentiate in the mucosa. By comparing the analogous monocyte differentiation process found in the dermis, we identify TGFβ as an indispensable part of monocyte differentiation in the intestine and show that it enables mφ to adapt precisely to the requirements of their environment. Importantly, TGFβR signaling on mφ has a crucial role in regulating the accumulation of monocytes in the mucosa, via mechanisms that are distinct from those used by IL10.
Original languageEnglish
Pages (from-to)1387–1399
JournalMucosal Immunology
Volume10
Issue number6
Early online date1 Feb 2017
DOIs
Publication statusPublished - Nov 2017

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