Tissue-specific differentiation of colonic macrophages requires TGFβ receptor-mediated signaling

A Schridde; C C Bain; J U  Mayer; J Montgomery; E Pollet; B Denecke; S W F Milling; S J Jenkins; M Dalod; S Henri; B Malissen; O Pabst; A Mcl Mowat

doi:10.1038/mi.2016.142

Tissue-specific differentiation of colonic macrophages requires TGFβ receptor-mediated signaling

A Schridde, C C Bain, J U Mayer, J Montgomery, E Pollet, B Denecke, S W F Milling, S J Jenkins, M Dalod, S Henri, B Malissen, O Pabst, A Mcl Mowat

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Abstract / Description of output

Intestinal macrophages (mφ) form one of the largest populations of mφ in the body and are vital for the maintenance of gut homeostasis. They have several unique properties and are derived from local differentiation of classical Ly6C^himonocytes, but the factors driving this tissue-specific process are not understood. Here we have used global transcriptomic analysis to identify a unique homeostatic signature of mature colonic mφ that is acquired as they differentiate in the mucosa. By comparing the analogous monocyte differentiation process found in the dermis, we identify TGFβ as an indispensable part of monocyte differentiation in the intestine and show that it enables mφ to adapt precisely to the requirements of their environment. Importantly, TGFβR signaling on mφ has a crucial role in regulating the accumulation of monocytes in the mucosa, via mechanisms that are distinct from those used by IL10.

Original language	English
Pages (from-to)	1387–1399
Journal	Mucosal Immunology
Volume	10
Issue number	6
Early online date	1 Feb 2017
DOIs	https://doi.org/10.1038/mi.2016.142
Publication status	Published - Nov 2017

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Calum Bain
- Deanery of Clinical Sciences - Senior Lecturer
- Centre for Inflammation Research
Person: Academic: Research Active

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title = "Tissue-specific differentiation of colonic macrophages requires TGFβ receptor-mediated signaling",

abstract = "Intestinal macrophages (mφ) form one of the largest populations of mφ in the body and are vital for the maintenance of gut homeostasis. They have several unique properties and are derived from local differentiation of classical Ly6Chi monocytes, but the factors driving this tissue-specific process are not understood. Here we have used global transcriptomic analysis to identify a unique homeostatic signature of mature colonic mφ that is acquired as they differentiate in the mucosa. By comparing the analogous monocyte differentiation process found in the dermis, we identify TGFβ as an indispensable part of monocyte differentiation in the intestine and show that it enables mφ to adapt precisely to the requirements of their environment. Importantly, TGFβR signaling on mφ has a crucial role in regulating the accumulation of monocytes in the mucosa, via mechanisms that are distinct from those used by IL10.",

author = "A Schridde and Bain, {C C} and Mayer, {J U} and J Montgomery and E Pollet and B Denecke and Milling, {S W F} and Jenkins, {S J} and M Dalod and S Henri and B Malissen and O Pabst and Mowat, {A Mcl}",

year = "2017",

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doi = "10.1038/mi.2016.142",

language = "English",

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T1 - Tissue-specific differentiation of colonic macrophages requires TGFβ receptor-mediated signaling

AU - Schridde, A

AU - Bain, C C

AU - Mayer, J U

AU - Montgomery, J

AU - Pollet, E

AU - Denecke, B

AU - Milling, S W F

AU - Jenkins, S J

AU - Dalod, M

AU - Henri, S

AU - Malissen, B

AU - Pabst, O

AU - Mowat, A Mcl

PY - 2017/11

Y1 - 2017/11

N2 - Intestinal macrophages (mφ) form one of the largest populations of mφ in the body and are vital for the maintenance of gut homeostasis. They have several unique properties and are derived from local differentiation of classical Ly6Chi monocytes, but the factors driving this tissue-specific process are not understood. Here we have used global transcriptomic analysis to identify a unique homeostatic signature of mature colonic mφ that is acquired as they differentiate in the mucosa. By comparing the analogous monocyte differentiation process found in the dermis, we identify TGFβ as an indispensable part of monocyte differentiation in the intestine and show that it enables mφ to adapt precisely to the requirements of their environment. Importantly, TGFβR signaling on mφ has a crucial role in regulating the accumulation of monocytes in the mucosa, via mechanisms that are distinct from those used by IL10.

AB - Intestinal macrophages (mφ) form one of the largest populations of mφ in the body and are vital for the maintenance of gut homeostasis. They have several unique properties and are derived from local differentiation of classical Ly6Chi monocytes, but the factors driving this tissue-specific process are not understood. Here we have used global transcriptomic analysis to identify a unique homeostatic signature of mature colonic mφ that is acquired as they differentiate in the mucosa. By comparing the analogous monocyte differentiation process found in the dermis, we identify TGFβ as an indispensable part of monocyte differentiation in the intestine and show that it enables mφ to adapt precisely to the requirements of their environment. Importantly, TGFβR signaling on mφ has a crucial role in regulating the accumulation of monocytes in the mucosa, via mechanisms that are distinct from those used by IL10.

U2 - 10.1038/mi.2016.142

DO - 10.1038/mi.2016.142

M3 - Article

SN - 1933-0219

VL - 10

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EP - 1399

JO - Mucosal Immunology

JF - Mucosal Immunology

IS - 6

ER -

Tissue-specific differentiation of colonic macrophages requires TGFβ receptor-mediated signaling

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Calum Bain

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