Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1

H Kubota, G M Hynes, S M Kerr, K R Willison

Research output: Contribution to journalArticlepeer-review

Abstract

We have cloned a novel Tcp-1-related mouse testis cDNA encoding a polypeptide of 531 amino acids which shares 81.2% identity with the zeta subunit of the mouse cytosolic chaperonin-containing TCP-1 (CCT). Immunoblot analysis of mouse testis CCT subunits separated by 2-dimensional gel electrophoresis indicates that this novel gene, Cctz-2, encodes a CCT subunit of Mr 57 000 and pI 7.1. Cctz-2 mRNA is detected only in testis whereas the other Cctz gene, Cctz-1, is expressed in all tissues investigated. The CCTzeta-2 subunit may have specific functions in the folding of testicular proteins and for interactions with testicular molecular chaperones.
Original languageEnglish
Pages (from-to)53-6
Number of pages4
JournalFEBS Letters
Volume402
Issue number1
DOIs
Publication statusPublished - 1997

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