TLR and B Cell Receptor Signals to B Cells Differentially Program Primary and Memory Th1 Responses to Salmonella enterica

Tom A. Barr, Sheila Brown, Pietro Mastroeni, David Gray

Research output: Contribution to journalArticlepeer-review

Abstract

Protective Th1 responses to Salmonella enterica do not develop in the absence of B cells. Using chimeric mice, we dissect the early (innate) and late (cognate) contributions of B cells to Th programming. B cell-intrinsic MyD88 signaling is required for primary effector Th1 development, whereas Ag-specific BCR-mediated Ag presentation is necessary for the development of memory Th1 populations. Programming of the primary T cell response is BCR/B cell MHC II independent, but requires MyD88-dependent secretion of cytokines by B cells. Chimeras in which B cells lack IFN-gamma or IL-6 genes make impaired Th1 or Th17 responses to Salmonella.

Original languageEnglish
Pages (from-to)2783-2789
Number of pages7
JournalJournal of Immunology
Volume185
Issue number5
DOIs
Publication statusPublished - 1 Sep 2010

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