TNF-alpha and adipocyte biology

William P. Cawthorn, Jaswinder K. Sethi*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Dyslipidemia and insulin resistance are commonly associated with catabolic or lipodystrophic conditions (such as cancer and sepsis) and with pathological states of nutritional overload (such as obesity-related type 2 diabetes). Two common features of these metabolic disorders are adipose tissue dysfunction and elevated levels of tumour necrosis factor-alpha (TNF-alpha). Herein, we review the multiple actions of this pro-inflammatory adipokine on adipose tissue biology. These include inhibition of carbohydrate metabolism, lipogenesis, adipogenesis and thermogenesis and stimulation of lipolysis. TNF-alpha can also impact the endocrine functions of adipose tissue. Taken together, TNF-alpha contributes to metabolic dysregulation by impairing both adipose tissue function and its ability to store excess fuel. The molecular mechanisms that underlie these actions are discussed. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)117-131
Number of pages15
JournalFEBS Letters
Volume582
Issue number1
DOIs
Publication statusPublished - 9 Jan 2008

Keywords

  • obesity
  • type 2 diabetes
  • metabolic syndrome
  • insulin resistance
  • dyslipidemia
  • TNF signalling
  • lipid metabolism
  • antiadipogenesis
  • TUMOR-NECROSIS-FACTOR
  • INDUCED INSULIN-RESISTANCE
  • PLASMINOGEN-ACTIVATOR INHIBITOR-1
  • HUMAN ADIPOSE-TISSUE
  • NF-KAPPA-B
  • ADIPONECTIN GENE-EXPRESSION
  • PLECKSTRIN HOMOLOGY DOMAIN
  • FETAL BROWN ADIPOCYTES
  • SIGNAL-RELATED KINASE
  • MESSENGER-RNA LEVELS

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