Abstract / Description of output
Dyslipidemia and insulin resistance are commonly associated with catabolic or lipodystrophic conditions (such as cancer and sepsis) and with pathological states of nutritional overload (such as obesity-related type 2 diabetes). Two common features of these metabolic disorders are adipose tissue dysfunction and elevated levels of tumour necrosis factor-alpha (TNF-alpha). Herein, we review the multiple actions of this pro-inflammatory adipokine on adipose tissue biology. These include inhibition of carbohydrate metabolism, lipogenesis, adipogenesis and thermogenesis and stimulation of lipolysis. TNF-alpha can also impact the endocrine functions of adipose tissue. Taken together, TNF-alpha contributes to metabolic dysregulation by impairing both adipose tissue function and its ability to store excess fuel. The molecular mechanisms that underlie these actions are discussed. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 117-131 |
| Number of pages | 15 |
| Journal | FEBS Letters |
| Volume | 582 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 9 Jan 2008 |
Keywords / Materials (for Non-textual outputs)
- obesity
- type 2 diabetes
- metabolic syndrome
- insulin resistance
- dyslipidemia
- TNF signalling
- lipid metabolism
- antiadipogenesis
- TUMOR-NECROSIS-FACTOR
- INDUCED INSULIN-RESISTANCE
- PLASMINOGEN-ACTIVATOR INHIBITOR-1
- HUMAN ADIPOSE-TISSUE
- NF-KAPPA-B
- ADIPONECTIN GENE-EXPRESSION
- PLECKSTRIN HOMOLOGY DOMAIN
- FETAL BROWN ADIPOCYTES
- SIGNAL-RELATED KINASE
- MESSENGER-RNA LEVELS