TNFR1 signaling and IFN-gamma signaling determine whether T cells induce tumor dormancy or promote multistage carcinogenesis

Nele Müller-Hermelink, Heidi Braumüller, Bernd Pichler, Thomas Wieder, Reinhard Mailhammer, Katrin Schaak, Kamran Ghoreschi, Amir Yazdi, Roland Haubner, Christian A Sander, Ralph Mocikat, Markus Schwaiger, Irmgard Förster, Ralph Huss, Wolfgang A Weber, Manfred Kneilling, Martin Röcken

Research output: Contribution to journalArticlepeer-review

Abstract

Immune responses may arrest tumor growth by inducing tumor dormancy. The mechanisms leading to either tumor dormancy or promotion of multistage carcinogenesis by adaptive immunity are poorly characterized. Analyzing T antigen (Tag)-induced multistage carcinogenesis in pancreatic islets, we show that Tag-specific CD4+ T cells home selectively into the tumor microenvironment around the islets, where they either arrest or promote transition of dysplastic islets into islet carcinomas. Through combined TNFR1 signaling and IFN-gamma signaling, Tag-specific CD4+ T cells induce antiangiogenic chemokines and prevent alpha(v)beta(3) integrin expression, tumor angiogenesis, tumor cell proliferation, and multistage carcinogenesis, without destroying Tag-expressing islet cells. In the absence of either TNFR1 signaling or IFN-gamma signaling, the same T cells paradoxically promote angiogenesis and multistage carcinogenesis. Thus, tumor-specific T cells can directly survey multistage carcinogenesis through cytokine signaling.

Original languageEnglish
Pages (from-to)507-18
Number of pages12
JournalCancer Cell
Volume13
Issue number6
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Animals
  • Antigens, Viral, Tumor
  • Blood Glucose
  • CD4-Positive T-Lymphocytes
  • Cell Movement
  • Cell Proliferation
  • Cell Survival
  • Cell Transformation, Neoplastic
  • Cells, Cultured
  • GTPase-Activating Proteins
  • Immunotherapy
  • Insulinoma
  • Integrin alphaVbeta3
  • Interferon-gamma
  • Mice
  • Mice, Inbred C3H
  • Mice, Knockout
  • Mice, Transgenic
  • Neovascularization, Pathologic
  • Pancreatic Neoplasms
  • Receptors, Tumor Necrosis Factor, Type I
  • Signal Transduction
  • Th1 Cells
  • Time Factors
  • Whole-Body Irradiation

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