Tolerance without clonal expansion: Self-antigen-expressing B cells program self-reactive T cells for future deletion

Friederike Frommer, Tobias J. A. J. Heinen, F. Thomas Wunderlich, Nir Yogev, Thorsten Buch, Axel Roers, Estelle Bettelli, Werner Mueller, Stephen M. Anderton, Ari Waisman

Research output: Contribution to journalArticlepeer-review

Abstract

B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity. We show that interaction of B cells with naive T cells results in T cell triggering accompanied by the expression of negative costimulatory molecules such as PD-1, CTLA-4, B and T lymphocyte attenuator, and CD5. Following interaction with B cells, T cells were not induced to proliferate, in a process that was dependent on their expression of PD-1 and CTLA-4, but not CD5. In contrast, the T cells became sensitive to Ag-induced cell death. Our results demonstrate that B cells participate in the homeostasis of the immune system by ablation of conventional self-reactive T cells.

Original languageEnglish
Pages (from-to)5748-5759
Number of pages12
JournalThe Journal of Immunology
Volume181
Issue number8
Publication statusPublished - 15 Oct 2008

Keywords

  • Animals
  • Antigens, CD/biosynthesis
  • Antigens, CD/genetics
  • Antigens, CD/immunology
  • Antigens, CD5/biosynthesis
  • Antigens, CD5/genetics
  • Antigens, CD5/immunology
  • Antigens, Differentiation/biosynthesis
  • Antigens, Differentiation/genetics
  • Antigens, Differentiation/immunology
  • Autoantigens/biosynthesis
  • Autoantigens/immunology
  • Autoimmunity/physiology
  • B-Lymphocytes/immunology
  • B-Lymphocytes/metabolism
  • CTLA-4 Antigen
  • Cell Proliferation
  • Clonal Deletion/physiology
  • Gene Expression Regulation/immunology
  • Homeostasis/immunology
  • Mice
  • Mice, Transgenic
  • T-Lymphocytes/immunology
  • T-Lymphocytes/metabolism

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