Abstract
Here, we detail the major developments in methods and techniques that are applicable to high-throughput synthesis that have evolved over the past five years, with an emphasis on the combination of microwave-based synthesis with techniques such as polymer-assisted purification and immobilized reagents and catalysts. Other aspects, such as automation, miniaturization and flow-based synthesis, are also presented as approaches that can be used for the rapid discovery and optimization of small organic molecules.
Original language | English |
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Pages (from-to) | 459-464 |
Number of pages | 6 |
Journal | Drug Discovery Today |
Volume | 12 |
Issue number | 11-12 |
DOIs | |
Publication status | Published - Jun 2007 |
Keywords
- POLYMER-SUPPORTED REAGENTS
- PHASE PEPTIDE-SYNTHESIS
- FLOW ORGANIC-SYNTHESIS
- DRUG DISCOVERY
- COMPOUND LIBRARIES
- TAGGED REAGENTS
- MICROWAVE-OVENS
- MICROREACTORS
- PURIFICATION
- SCAVENGERS