Tools for efficient high-throughput synthesis

Alessandra Chighine, Gianluca Sechi, Mark Bradley

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Here, we detail the major developments in methods and techniques that are applicable to high-throughput synthesis that have evolved over the past five years, with an emphasis on the combination of microwave-based synthesis with techniques such as polymer-assisted purification and immobilized reagents and catalysts. Other aspects, such as automation, miniaturization and flow-based synthesis, are also presented as approaches that can be used for the rapid discovery and optimization of small organic molecules.

Original languageEnglish
Pages (from-to)459-464
Number of pages6
JournalDrug Discovery Today
Volume12
Issue number11-12
DOIs
Publication statusPublished - Jun 2007

Keywords

  • POLYMER-SUPPORTED REAGENTS
  • PHASE PEPTIDE-SYNTHESIS
  • FLOW ORGANIC-SYNTHESIS
  • DRUG DISCOVERY
  • COMPOUND LIBRARIES
  • TAGGED REAGENTS
  • MICROWAVE-OVENS
  • MICROREACTORS
  • PURIFICATION
  • SCAVENGERS

Cite this