Topography of cancer-associated immune cells in human solid tumors

Jakob Nikolas Kather; Meggy Suarez-Carmona; Pornpimol Charoentong; Cleo-Aron Weis; Daniela Hirsch; Peter Bankhead; Marcel Horning; Dyke Ferber; Ivan Kel; Esther Herpel; Sarah Schott; Inka Zörnig; Jochen Utikal; Alexander Marx; Timo Gaiser; Herrmann Brenner; Jenny Chang-Claude; Michael Hoffmeister; Dirk Jäger; Niels Halama

doi:10.7554/eLife.36967

Topography of cancer-associated immune cells in human solid tumors

Jakob Nikolas Kather, Meggy Suarez-Carmona, Pornpimol Charoentong, Cleo-Aron Weis, Daniela Hirsch, Peter Bankhead, Marcel Horning, Dyke Ferber, Ivan Kel, Esther Herpel, Sarah Schott, Inka Zörnig, Jochen Utikal, Alexander Marx, Timo Gaiser, Herrmann Brenner, Jenny Chang-Claude, Michael Hoffmeister, Dirk Jäger, Niels Halama

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Abstract / Description of output

Lymphoid and myeloid cells are abundant in the tumor microenvironment, can be quantified by immunohistochemistry and shape the disease course of human solid tumors. Yet, there is no comprehensive understanding of spatial immune infiltration patterns (‘topography’) across cancer entities and across various immune cell types. In this study, we systematically measure the topography of multiple immune cell types in 965 histological tissue slides from N = 177 patients in a pan-cancer cohort. We provide a definition of inflamed (‘hot’), non-inflamed (‘cold’) and immune excluded patterns and investigate how these patterns differ between immune cell types and between cancer types. In an independent cohort of N = 287 colorectal cancer patients, we show that hot, cold and excluded topographies for effector lymphocytes (CD8) and tumor-associated macrophages (CD163) alone are not prognostic, but that a bivariate classification system can stratify patients. Our study adds evidence to consider immune topographies as biomarkers for patients with solid tumors.

Original language	English
Article number	e36967
Number of pages	19
Journal	eLIFE
Volume	7
Early online date	4 Sept 2018
DOIs	https://doi.org/10.7554/eLife.36967
Publication status	Published - 11 Sept 2018

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10.7554/eLife.36967

elife-36967-v2
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Peter Bankhead
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Kather, J. N., Suarez-Carmona, M., Charoentong, P., Weis, C.-A., Hirsch, D., Bankhead, P., Horning, M., Ferber, D., Kel, I., Herpel, E., Schott, S., Zörnig, I., Utikal, J., Marx, A., Gaiser, T., Brenner, H., Chang-Claude, J., Hoffmeister, M., Jäger, D., & Halama, N. (2018). Topography of cancer-associated immune cells in human solid tumors. eLIFE, 7, Article e36967. https://doi.org/10.7554/eLife.36967

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title = "Topography of cancer-associated immune cells in human solid tumors",

abstract = "Lymphoid and myeloid cells are abundant in the tumor microenvironment, can be quantified by immunohistochemistry and shape the disease course of human solid tumors. Yet, there is no comprehensive understanding of spatial immune infiltration patterns ({\textquoteleft}topography{\textquoteright}) across cancer entities and across various immune cell types. In this study, we systematically measure the topography of multiple immune cell types in 965 histological tissue slides from N = 177 patients in a pan-cancer cohort. We provide a definition of inflamed ({\textquoteleft}hot{\textquoteright}), non-inflamed ({\textquoteleft}cold{\textquoteright}) and immune excluded patterns and investigate how these patterns differ between immune cell types and between cancer types. In an independent cohort of N = 287 colorectal cancer patients, we show that hot, cold and excluded topographies for effector lymphocytes (CD8) and tumor-associated macrophages (CD163) alone are not prognostic, but that a bivariate classification system can stratify patients. Our study adds evidence to consider immune topographies as biomarkers for patients with solid tumors.",

author = "Kather, {Jakob Nikolas} and Meggy Suarez-Carmona and Pornpimol Charoentong and Cleo-Aron Weis and Daniela Hirsch and Peter Bankhead and Marcel Horning and Dyke Ferber and Ivan Kel and Esther Herpel and Sarah Schott and Inka Z{\"o}rnig and Jochen Utikal and Alexander Marx and Timo Gaiser and Herrmann Brenner and Jenny Chang-Claude and Michael Hoffmeister and Dirk J{\"a}ger and Niels Halama",

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year = "2018",

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day = "11",

doi = "10.7554/eLife.36967",

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Kather, JN, Suarez-Carmona, M, Charoentong, P, Weis, C-A, Hirsch, D, Bankhead, P, Horning, M, Ferber, D, Kel, I, Herpel, E, Schott, S, Zörnig, I, Utikal, J, Marx, A, Gaiser, T, Brenner, H, Chang-Claude, J, Hoffmeister, M, Jäger, D & Halama, N 2018, 'Topography of cancer-associated immune cells in human solid tumors', eLIFE, vol. 7, e36967. https://doi.org/10.7554/eLife.36967

TY - JOUR

T1 - Topography of cancer-associated immune cells in human solid tumors

AU - Kather, Jakob Nikolas

AU - Suarez-Carmona, Meggy

AU - Charoentong, Pornpimol

AU - Weis, Cleo-Aron

AU - Hirsch, Daniela

AU - Bankhead, Peter

AU - Horning, Marcel

AU - Ferber, Dyke

AU - Kel, Ivan

AU - Herpel, Esther

AU - Schott, Sarah

AU - Zörnig, Inka

AU - Utikal, Jochen

AU - Marx, Alexander

AU - Gaiser, Timo

AU - Brenner, Herrmann

AU - Chang-Claude, Jenny

AU - Hoffmeister, Michael

AU - Jäger, Dirk

AU - Halama, Niels

PY - 2018/9/11

Y1 - 2018/9/11

N2 - Lymphoid and myeloid cells are abundant in the tumor microenvironment, can be quantified by immunohistochemistry and shape the disease course of human solid tumors. Yet, there is no comprehensive understanding of spatial immune infiltration patterns (‘topography’) across cancer entities and across various immune cell types. In this study, we systematically measure the topography of multiple immune cell types in 965 histological tissue slides from N = 177 patients in a pan-cancer cohort. We provide a definition of inflamed (‘hot’), non-inflamed (‘cold’) and immune excluded patterns and investigate how these patterns differ between immune cell types and between cancer types. In an independent cohort of N = 287 colorectal cancer patients, we show that hot, cold and excluded topographies for effector lymphocytes (CD8) and tumor-associated macrophages (CD163) alone are not prognostic, but that a bivariate classification system can stratify patients. Our study adds evidence to consider immune topographies as biomarkers for patients with solid tumors.

AB - Lymphoid and myeloid cells are abundant in the tumor microenvironment, can be quantified by immunohistochemistry and shape the disease course of human solid tumors. Yet, there is no comprehensive understanding of spatial immune infiltration patterns (‘topography’) across cancer entities and across various immune cell types. In this study, we systematically measure the topography of multiple immune cell types in 965 histological tissue slides from N = 177 patients in a pan-cancer cohort. We provide a definition of inflamed (‘hot’), non-inflamed (‘cold’) and immune excluded patterns and investigate how these patterns differ between immune cell types and between cancer types. In an independent cohort of N = 287 colorectal cancer patients, we show that hot, cold and excluded topographies for effector lymphocytes (CD8) and tumor-associated macrophages (CD163) alone are not prognostic, but that a bivariate classification system can stratify patients. Our study adds evidence to consider immune topographies as biomarkers for patients with solid tumors.

U2 - 10.7554/eLife.36967

DO - 10.7554/eLife.36967

M3 - Article

C2 - 30179157

SN - 2050-084X

VL - 7

JO - eLIFE

JF - eLIFE

M1 - e36967

ER -

Topography of cancer-associated immune cells in human solid tumors

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Peter Bankhead

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