Total MRI load of cerebral small vessel disease and cognitive ability in older people

Julie Staals; Tom Booth; Zoe Morris; Mark E. Bastin; Alan J. Gow; Janie Corley; Paul Redmond; John Starr; Ian J. Deary; Joanna M. Wardlaw

doi:10.1016/j.neurobiolaging.2015.06.024

Total MRI load of cerebral small vessel disease and cognitive ability in older people

Julie Staals, Tom Booth, Zoe Morris, Mark E. Bastin, Alan J. Gow, Janie Corley, Paul Redmond, John Starr, Ian J. Deary, Joanna M. Wardlaw

Research output: Contribution to journal › Article › peer-review

Abstract

Cerebral small vessel disease (SVD) may cause cognitive dysfunction. We tested the association between the combined presence of magnetic resonance imaging (MRI) features of SVD and cognitive ability in older age. Cognitive testing and brain MRI were performed in 680 older participants. MRI presence of lacunes, white matter hyperintensities, microbleeds, and perivascular spaces were summed in a score of 0–4 representing all SVD features combined. We also applied latent variable modeling to test whether the 4 MRI features form a unitary SVD construct. The SVD score showed significant associations with general cognitive ability. Latent variable modeling indicated that the 4 MRI markers formed a unitary construct, which showed consistent associations with cognitive ability compared with the SVD score. Total MRI load of SVD is associated with lower general cognitive ability in older age. The total SVD score performed consistently with the more complex latent variable model, suggesting validity and potential utility in future research for determining total SVD load.

Original language	English
Pages (from-to)	2806-2811
Journal	Neurobiology of Aging
Volume	36
Issue number	10
Early online date	26 Jun 2015
DOIs	https://doi.org/10.1016/j.neurobiolaging.2015.06.024
Publication status	Published - 31 Oct 2015

Keywords / Materials (for Non-textual outputs)

MRI
cerebral small vessel disease
cognitive ability

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10.1016/j.neurobiolaging.2015.06.024Licence: Creative Commons: Attribution (CC-BY)

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Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III
Wardlaw, J., Bastin, M. & Deary, I.
MRC
1/05/15 → 30/04/19
Project: Research
Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
Maclullich, A.
1/09/13 → 31/08/19
Project: Research
RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I., Gale, C., Holmes, M., Logie, P., Maclullich, A., Porteous, D., Seckl, J., Starr, J., Wardlaw, J. & Okely, J.
1/09/13 → 31/08/19
Project: Research

Cite this

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title = "Total MRI load of cerebral small vessel disease and cognitive ability in older people",

abstract = "Cerebral small vessel disease (SVD) may cause cognitive dysfunction. We tested the association between the combined presence of magnetic resonance imaging (MRI) features of SVD and cognitive ability in older age. Cognitive testing and brain MRI were performed in 680 older participants. MRI presence of lacunes, white matter hyperintensities, microbleeds, and perivascular spaces were summed in a score of 0–4 representing all SVD features combined. We also applied latent variable modeling to test whether the 4 MRI features form a unitary SVD construct. The SVD score showed significant associations with general cognitive ability. Latent variable modeling indicated that the 4 MRI markers formed a unitary construct, which showed consistent associations with cognitive ability compared with the SVD score. Total MRI load of SVD is associated with lower general cognitive ability in older age. The total SVD score performed consistently with the more complex latent variable model, suggesting validity and potential utility in future research for determining total SVD load.",

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AU - Booth, Tom

AU - Morris, Zoe

AU - Bastin, Mark E.

AU - Gow, Alan J.

AU - Corley, Janie

AU - Redmond, Paul

AU - Starr, John

AU - Deary, Ian J.

AU - Wardlaw, Joanna M.

PY - 2015/10/31

Y1 - 2015/10/31

N2 - Cerebral small vessel disease (SVD) may cause cognitive dysfunction. We tested the association between the combined presence of magnetic resonance imaging (MRI) features of SVD and cognitive ability in older age. Cognitive testing and brain MRI were performed in 680 older participants. MRI presence of lacunes, white matter hyperintensities, microbleeds, and perivascular spaces were summed in a score of 0–4 representing all SVD features combined. We also applied latent variable modeling to test whether the 4 MRI features form a unitary SVD construct. The SVD score showed significant associations with general cognitive ability. Latent variable modeling indicated that the 4 MRI markers formed a unitary construct, which showed consistent associations with cognitive ability compared with the SVD score. Total MRI load of SVD is associated with lower general cognitive ability in older age. The total SVD score performed consistently with the more complex latent variable model, suggesting validity and potential utility in future research for determining total SVD load.

AB - Cerebral small vessel disease (SVD) may cause cognitive dysfunction. We tested the association between the combined presence of magnetic resonance imaging (MRI) features of SVD and cognitive ability in older age. Cognitive testing and brain MRI were performed in 680 older participants. MRI presence of lacunes, white matter hyperintensities, microbleeds, and perivascular spaces were summed in a score of 0–4 representing all SVD features combined. We also applied latent variable modeling to test whether the 4 MRI features form a unitary SVD construct. The SVD score showed significant associations with general cognitive ability. Latent variable modeling indicated that the 4 MRI markers formed a unitary construct, which showed consistent associations with cognitive ability compared with the SVD score. Total MRI load of SVD is associated with lower general cognitive ability in older age. The total SVD score performed consistently with the more complex latent variable model, suggesting validity and potential utility in future research for determining total SVD load.

KW - MRI

KW - cerebral small vessel disease

KW - cognitive ability

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JO - Neurobiology of Aging

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Total MRI load of cerebral small vessel disease and cognitive ability in older people

Abstract

Keywords / Materials (for Non-textual outputs)

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Projects

Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

Cite this