Total Synthesis of a Dimeric Thymol Derivative Isolated from Arnica sachalinensis

Samuel L. Drew, Fernanda Duarte Gonzalez, Irene De silvestro, Andrew Lawrence, Gary Nichol

Research output: Contribution to journalArticlepeer-review

Abstract

The total synthesis of a dimeric thymol derivative (thymarnicol) isolated from Arnica sachalinensis was accomplished in 6 steps. A key biomimetic Diels–Alder dimerization was found to occur at ambient temperature and the final oxidative cyclization occurs when the substrate is exposed to air and visible light. These results indicate that this natural product is likely the result of spontaneous (non-enzyme-mediated) reactivity.
Original languageEnglish
JournalAngewandte Chemie
Early online date5 May 2017
DOIs
Publication statusPublished - 5 May 2017

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