Toward a Molecular Structure of the Eukaryotic Kinetochore

Julie P. I. Welburn, Iain M. Cheeseman

Research output: Contribution to journalEditorialpeer-review

Abstract

Chromosome segregation in eukaryotes requires a large molecular assembly termed the kinetochore to attach chromosomes to spindle microtubules. Recent work has made substantial progress in defining the composition and activities of the kinetochore, but much remains to be learned about its macromolecular structure. This commentary discusses recent insights into structural features of the kinetochore, how these inform our understanding of its biological function, and the key challenges for the future.

Original languageEnglish
Pages (from-to)645-655
Number of pages11
JournalDevelopmental Cell
Volume15
Issue number5
DOIs
Publication statusPublished - 11 Nov 2008

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