Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report

Michelle L. Gumz; Daichi Shimbo; Marwah Abdalla; Ravi C. Balijepalli; Christian Benedict; Yabing Chen; David J. Earnest; Karen L. Gamble; Scott R. Garrison; Ming C. Gong; John B. Hogenesch; Yuling Hong; Jessica R. Ivy; Bina Joe; Aaron D. Laposky; Mingyu Liang; Eric J. Maclaughlin; Tami A. Martino; David M. Pollock; Susan Redline; Amy Rogers; R. Dan Rudic; Eva S. Schernhammer; George S. Stergiou; Marie-pierre St-onge; Xiaoling Wang; Jacqueline Wright; Young S. Oh

Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report

Michelle L. Gumz, Daichi Shimbo, Marwah Abdalla, Ravi C. Balijepalli, Christian Benedict, Yabing Chen, David J. Earnest, Karen L. Gamble, Scott R. Garrison, Ming C. Gong, John B. Hogenesch, Yuling Hong, Jessica R. Ivy, Bina Joe, Aaron D. Laposky, Mingyu Liang, Eric J. Maclaughlin, Tami A. Martino, David M. Pollock, Susan RedlineAmy Rogers, R. Dan Rudic, Eva S. Schernhammer, George S. Stergiou, Marie-pierre St-onge, Xiaoling Wang, Jacqueline Wright, Young S. Oh

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

Healthy individuals exhibit blood pressure variation over a 24-hour period with higher blood pressure during
wakefulness and lower blood pressure during sleep. Loss or disruption of the blood pressure circadian rhythm has been
linked to adverse health outcomes, for example, cardiovascular disease, dementia, and chronic kidney disease. However,
the current diagnostic and therapeutic approaches lack sufficient attention to the circadian rhythmicity of blood pressure.
Sleep patterns, hormone release, eating habits, digestion, body temperature, renal and cardiovascular function, and other
important host functions as well as gut microbiota exhibit circadian rhythms, and influence circadian rhythms of blood
pressure. Potential benefits of nonpharmacologic interventions such as meal timing, and pharmacologic chronotherapeutic
interventions, such as the bedtime administration of antihypertensive medications, have recently been suggested in some
studies. However, the mechanisms underlying circadian rhythm-mediated blood pressure regulation and the efficacy of
chronotherapy in hypertension remain unclear. This review summarizes the results of the National Heart, Lung, and Blood
Institute workshop convened on October 27 to 29, 2021 to assess knowledge gaps and research opportunities in the study
of circadian rhythm of blood pressure and chronotherapy for hypertension.

Original language	English
Journal	Hypertension
Publication status	Published - 30 Nov 2022

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.122.19372

Glucocorticoids and non-dipping blood pressure: renal tubular and vascular mechanisms
Ivy, J. & Bailey, M.
UK-based charities
1/12/19 → 30/11/22
Project: Research

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Gumz, M. L., Shimbo, D., Abdalla, M., Balijepalli, R. C., Benedict, C., Chen, Y., Earnest, D. J., Gamble, K. L., Garrison, S. R., Gong, M. C., Hogenesch, J. B., Hong, Y., Ivy, J. R., Joe, B., Laposky, A. D., Liang, M., Maclaughlin, E. J., Martino, T. A., Pollock, D. M., ... Oh, Y. S. (2022). Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report. Hypertension. https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.122.19372

@article{0c4cf52bfc9a4b2f8c2769d328f707a3,

title = "Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report",

abstract = "Healthy individuals exhibit blood pressure variation over a 24-hour period with higher blood pressure duringwakefulness and lower blood pressure during sleep. Loss or disruption of the blood pressure circadian rhythm has beenlinked to adverse health outcomes, for example, cardiovascular disease, dementia, and chronic kidney disease. However,the current diagnostic and therapeutic approaches lack sufficient attention to the circadian rhythmicity of blood pressure.Sleep patterns, hormone release, eating habits, digestion, body temperature, renal and cardiovascular function, and otherimportant host functions as well as gut microbiota exhibit circadian rhythms, and influence circadian rhythms of bloodpressure. Potential benefits of nonpharmacologic interventions such as meal timing, and pharmacologic chronotherapeuticinterventions, such as the bedtime administration of antihypertensive medications, have recently been suggested in somestudies. However, the mechanisms underlying circadian rhythm-mediated blood pressure regulation and the efficacy ofchronotherapy in hypertension remain unclear. This review summarizes the results of the National Heart, Lung, and BloodInstitute workshop convened on October 27 to 29, 2021 to assess knowledge gaps and research opportunities in the studyof circadian rhythm of blood pressure and chronotherapy for hypertension.",

author = "Gumz, {Michelle L.} and Daichi Shimbo and Marwah Abdalla and Balijepalli, {Ravi C.} and Christian Benedict and Yabing Chen and Earnest, {David J.} and Gamble, {Karen L.} and Garrison, {Scott R.} and Gong, {Ming C.} and Hogenesch, {John B.} and Yuling Hong and Ivy, {Jessica R.} and Bina Joe and Laposky, {Aaron D.} and Mingyu Liang and Maclaughlin, {Eric J.} and Martino, {Tami A.} and Pollock, {David M.} and Susan Redline and Amy Rogers and {Dan Rudic}, R. and Schernhammer, {Eva S.} and Stergiou, {George S.} and Marie-pierre St-onge and Xiaoling Wang and Jacqueline Wright and Oh, {Young S.}",

year = "2022",

month = nov,

day = "30",

language = "English",

journal = "Hypertension",

issn = "0194-911X",

publisher = "Lippincott Williams & Wilkins",

}

Gumz, ML, Shimbo, D, Abdalla, M, Balijepalli, RC, Benedict, C, Chen, Y, Earnest, DJ, Gamble, KL, Garrison, SR, Gong, MC, Hogenesch, JB, Hong, Y, Ivy, JR, Joe, B, Laposky, AD, Liang, M, Maclaughlin, EJ, Martino, TA, Pollock, DM, Redline, S, Rogers, A, Dan Rudic, R, Schernhammer, ES, Stergiou, GS, St-onge, M, Wang, X, Wright, J & Oh, YS 2022, 'Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report', Hypertension. <https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.122.19372>

TY - JOUR

T1 - Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report

AU - Gumz, Michelle L.

AU - Shimbo, Daichi

AU - Abdalla, Marwah

AU - Balijepalli, Ravi C.

AU - Benedict, Christian

AU - Chen, Yabing

AU - Earnest, David J.

AU - Gamble, Karen L.

AU - Garrison, Scott R.

AU - Gong, Ming C.

AU - Hogenesch, John B.

AU - Hong, Yuling

AU - Ivy, Jessica R.

AU - Joe, Bina

AU - Laposky, Aaron D.

AU - Liang, Mingyu

AU - Maclaughlin, Eric J.

AU - Martino, Tami A.

AU - Pollock, David M.

AU - Redline, Susan

AU - Rogers, Amy

AU - Dan Rudic, R.

AU - Schernhammer, Eva S.

AU - Stergiou, George S.

AU - St-onge, Marie-pierre

AU - Wang, Xiaoling

AU - Wright, Jacqueline

AU - Oh, Young S.

PY - 2022/11/30

Y1 - 2022/11/30

N2 - Healthy individuals exhibit blood pressure variation over a 24-hour period with higher blood pressure duringwakefulness and lower blood pressure during sleep. Loss or disruption of the blood pressure circadian rhythm has beenlinked to adverse health outcomes, for example, cardiovascular disease, dementia, and chronic kidney disease. However,the current diagnostic and therapeutic approaches lack sufficient attention to the circadian rhythmicity of blood pressure.Sleep patterns, hormone release, eating habits, digestion, body temperature, renal and cardiovascular function, and otherimportant host functions as well as gut microbiota exhibit circadian rhythms, and influence circadian rhythms of bloodpressure. Potential benefits of nonpharmacologic interventions such as meal timing, and pharmacologic chronotherapeuticinterventions, such as the bedtime administration of antihypertensive medications, have recently been suggested in somestudies. However, the mechanisms underlying circadian rhythm-mediated blood pressure regulation and the efficacy ofchronotherapy in hypertension remain unclear. This review summarizes the results of the National Heart, Lung, and BloodInstitute workshop convened on October 27 to 29, 2021 to assess knowledge gaps and research opportunities in the studyof circadian rhythm of blood pressure and chronotherapy for hypertension.

AB - Healthy individuals exhibit blood pressure variation over a 24-hour period with higher blood pressure duringwakefulness and lower blood pressure during sleep. Loss or disruption of the blood pressure circadian rhythm has beenlinked to adverse health outcomes, for example, cardiovascular disease, dementia, and chronic kidney disease. However,the current diagnostic and therapeutic approaches lack sufficient attention to the circadian rhythmicity of blood pressure.Sleep patterns, hormone release, eating habits, digestion, body temperature, renal and cardiovascular function, and otherimportant host functions as well as gut microbiota exhibit circadian rhythms, and influence circadian rhythms of bloodpressure. Potential benefits of nonpharmacologic interventions such as meal timing, and pharmacologic chronotherapeuticinterventions, such as the bedtime administration of antihypertensive medications, have recently been suggested in somestudies. However, the mechanisms underlying circadian rhythm-mediated blood pressure regulation and the efficacy ofchronotherapy in hypertension remain unclear. This review summarizes the results of the National Heart, Lung, and BloodInstitute workshop convened on October 27 to 29, 2021 to assess knowledge gaps and research opportunities in the studyof circadian rhythm of blood pressure and chronotherapy for hypertension.

M3 - Review article

SN - 0194-911X

JO - Hypertension

JF - Hypertension

ER -

Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report

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Glucocorticoids and non-dipping blood pressure: renal tubular and vascular mechanisms

Cite this