TY - GEN
T1 - Towards a smartphone-aided electronic ELISA for real-time electrochemical monitoring
AU - Pechlivanidis, Nikolaos G.
AU - Papadimitriou, Konstantinos I.
AU - Evans, Daniel
AU - Vasilakis, Nikolaos
AU - Prodromakis, Themistoklis
N1 - Funding Information:
The authors acknowledge the financial support of the Engineering and Physical Sciences Research Council (EPSRC), EP/L020920/1 research grant.
Publisher Copyright:
© 2017 IEEE.
PY - 2017/9/28
Y1 - 2017/9/28
N2 - This paper details the design and fabrication of a portable, smartphone-integrated electronic platform, tailored to read-out electronic ELISA (eELISA) data from printed circuit board (PCB)-based sensors. The instrument features eight independent, re-configurable current input channels, each consisting of a low-noise transimpedance amplifier (TIA) and filtering stage coupled to low-noise switch ICs for automatic current range detection. A bipolar, 16-bit resolution voltage-input analog-to-digital converter (ADC) has been employed for digitisation of converted current values received from the analogue front-end. In addition, a bipolar, 12-bit resolution digital-to-analog converter (DAC) combined with standard three-electrode potentiostats provides wide range biasing voltages to the amperometric sensors. The resulting digital data is transmitted via serial interface to an Android-based smartphone, where an ergonomic user interface guides the operator through the detection process. The customised Android application (App) provides real-time monitoring of the electrochemical cell and stores returned biochemical data on the device once measurement is complete.
AB - This paper details the design and fabrication of a portable, smartphone-integrated electronic platform, tailored to read-out electronic ELISA (eELISA) data from printed circuit board (PCB)-based sensors. The instrument features eight independent, re-configurable current input channels, each consisting of a low-noise transimpedance amplifier (TIA) and filtering stage coupled to low-noise switch ICs for automatic current range detection. A bipolar, 16-bit resolution voltage-input analog-to-digital converter (ADC) has been employed for digitisation of converted current values received from the analogue front-end. In addition, a bipolar, 12-bit resolution digital-to-analog converter (DAC) combined with standard three-electrode potentiostats provides wide range biasing voltages to the amperometric sensors. The resulting digital data is transmitted via serial interface to an Android-based smartphone, where an ergonomic user interface guides the operator through the detection process. The customised Android application (App) provides real-time monitoring of the electrochemical cell and stores returned biochemical data on the device once measurement is complete.
KW - Amperometry
KW - Analog-to-Digital Conversion
KW - Bioin-strumentation
KW - eELISA
KW - Lab-on-PCB
KW - Smartphone-Aided
UR - http://www.scopus.com/inward/record.url?scp=85032654661&partnerID=8YFLogxK
U2 - 10.1109/ISCAS.2017.8050616
DO - 10.1109/ISCAS.2017.8050616
M3 - Conference contribution
AN - SCOPUS:85032654661
T3 - Proceedings - IEEE International Symposium on Circuits and Systems
BT - IEEE International Symposium on Circuits and Systems
PB - Institute of Electrical and Electronics Engineers
T2 - 50th IEEE International Symposium on Circuits and Systems, ISCAS 2017
Y2 - 28 May 2017 through 31 May 2017
ER -