TY - JOUR
T1 - Towards diagnostic markers for the psychoses
AU - Lawrie, Stephen M.
AU - O'Donovan, Michael C.
AU - Saks, Elyn
AU - Burns, Tom
AU - Lieberman, Jeffrey A.
PY - 2016/4
Y1 - 2016/4
N2 - Psychotic disorders are currently grouped under broad phenomenological diagnostic rubrics. Researchers hope that progress in identifying aetiological mechanisms will ultimately enable more precise division of heterogeneous diagnoses into specific and valid subgroups. This goal has been an aim of psychiatry since the 19th century, when patients with general paresis were thought to have "insanity" similar to dementia praecox and manic depressive illness. Nowadays, the constructs of organic-induced and substance-induced psychotic disorder show that our diagnostic classification system already reflects, in part, aetiological factors. Most recently, gene copy number variation and autoimmunity have been associated with schizophrenia. We suggest how, on the basis of recent scientific advances, we can progress the identification of further putative subgroups and make the most of currently available interventions. Prompt diagnosis and treatment, and a more routine search for causes, could preserve function and improve outcome, and therefore be more acceptable to patients and carers.
AB - Psychotic disorders are currently grouped under broad phenomenological diagnostic rubrics. Researchers hope that progress in identifying aetiological mechanisms will ultimately enable more precise division of heterogeneous diagnoses into specific and valid subgroups. This goal has been an aim of psychiatry since the 19th century, when patients with general paresis were thought to have "insanity" similar to dementia praecox and manic depressive illness. Nowadays, the constructs of organic-induced and substance-induced psychotic disorder show that our diagnostic classification system already reflects, in part, aetiological factors. Most recently, gene copy number variation and autoimmunity have been associated with schizophrenia. We suggest how, on the basis of recent scientific advances, we can progress the identification of further putative subgroups and make the most of currently available interventions. Prompt diagnosis and treatment, and a more routine search for causes, could preserve function and improve outcome, and therefore be more acceptable to patients and carers.
UR - http://www.scopus.com/inward/record.url?scp=84962468707&partnerID=8YFLogxK
U2 - 10.1016/S2215-0366(16)00021-3
DO - 10.1016/S2215-0366(16)00021-3
M3 - Article
AN - SCOPUS:84962468707
SN - 2215-0366
VL - 3
SP - 375
EP - 385
JO - The Lancet Psychiatry
JF - The Lancet Psychiatry
IS - 4
ER -