Towards host-directed therapies for tuberculosis

Host-Directed Therapies Network, Alimuddin Zumla, Markus Maeurer, Jeremiah Chakaya, Michael Hoelscher, Francine Ntoumi, Roxana Rustomjee, Cristina Vilaplana, Dorothy Yeboah-Manu, Voahangy Rasolof, Paula Munderi, Nalini Singh, Eleni Aklillu, Nesri Padayatchi, Eusebio Macete, Nathan Kapata, Modest Mulenga, Gibson Kibiki, Sayoki Mfinanga, Thomas NyirendaLeonard Maboko, Alberto Garcia-Basteiro, Niaina Rakotosamimanana, Matthew Bates, Peter Mwaba, Klaus Reither, Sebastien Gagneux, Sarah Edwards, Elirehema Mfinanga, Salim Abdulla, Pere-Joan Cardona, James B W Russell, Vanya Gant, Mahdad Noursadeghi, Paul Elkington, Maryline Bonnet, Clara Menendez, Tandakha N Dieye, Bassirou Diarra, Almoustapha Maiga, Abraham Aseffa, Shreemanta Parida, Christian Wejse, Eskild Petersen, Pontiano Kaleebu, Matt Oliver, Gill Craig, Tumena Corrah, Leopold Tientcheu, Martin Antonio, Aziz Sheikh

Research output: Contribution to journalArticlepeer-review

Abstract

The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis. A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies.

Original languageEnglish
Pages (from-to)511-2
Number of pages2
JournalNature Reviews Drug Discovery
Volume14
Issue number8
DOIs
Publication statusPublished - 17 Jul 2015

Keywords

  • Antitubercular Agents
  • Drug Design
  • Drug Therapy, Combination
  • Humans
  • Molecular Targeted Therapy
  • Mycobacterium tuberculosis
  • Tuberculosis

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