Towards increased reliability, transparency and accessibility in crosslinking mass spectrometry

Alexander Leitner, Alexandre M.J.J. Bonvin, Christoph H Borchers, Robert J. Chalkley, Julie Chamot-Rooke, Colin Combe, Jürgen Cox, Meng-Qiu Dong, Lutz Fischer, Michael Götze, Fabio C. Gozzo, Albert J R Heck, Michael R. Hoopmann, Lan Huang, Yasushi Ishihama, Andrew R. Jones, Nir Kalisman, Oliver Kohlbacher, Karl Mechtler, Robert L. MoritzEugen Netz, Petr Novak, Evgeniy Petrotchenko, Andrej Sali, Richard A. Scheltema, Carla Schmidt, David C. Schriemer, Andrea Sinz, Frank Sobott, Florian Stengel, Konstantinos Thalassinos, Henning Urlaub, Rosa Viner, Juan A. Vizcaino, Marc R Wilkins, Juri Rappsilber

Research output: Contribution to journalArticlepeer-review

Abstract

Crosslinking mass spectrometry (Crosslinking MS) has substantially matured as a method over the last two decades through parallel development in multiple labs, demonstrating its applicability for protein structure determination, conformation analysis and mapping protein interactions in complex mixtures. Crosslinking MS has become a much-appreciated and routinely applied tool, especially in structural biology. Therefore, it is timely that the community commits to the development of methodological and reporting standards. This white paper builds on an open process comprising a number of events at community conferences since 2015 and identifies aspects of Crosslinking MS for which guidelines should be developed as part of a Crosslinking MS standards initiative.
Original languageEnglish
Pages (from-to)1259-1268
Number of pages10
JournalStructure
Volume28
Issue number11
Early online date15 Oct 2020
DOIs
Publication statusPublished - 3 Nov 2020

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