TY - JOUR
T1 - Toxicity of Chemotherapy and Radiation on Female Reproduction
AU - Meirow, Dror
AU - Biederman, Hannah
AU - Anderson, Richard A.
AU - Wallace, W. Hamish B.
PY - 2010/12
Y1 - 2010/12
N2 - One of the most devastating consequences of cancer treatment in the young female population is ovarian damage, resulting in diminished fertility potential. The extent of damage is related to age, chemotherapeutic regimen, and dose of pelvic radiation received. It is crucial that physicians know the impact each of these factors has on future fertility to advice patients on fertility preservation options. Anticancer drugs injure the female reproductive system through ovarian follicular and stromal damage. Although the exact mechanisms of damage remain unclear, it is essential to better understand these mechanisms to develop methods to diminish ovarian injury.
AB - One of the most devastating consequences of cancer treatment in the young female population is ovarian damage, resulting in diminished fertility potential. The extent of damage is related to age, chemotherapeutic regimen, and dose of pelvic radiation received. It is crucial that physicians know the impact each of these factors has on future fertility to advice patients on fertility preservation options. Anticancer drugs injure the female reproductive system through ovarian follicular and stromal damage. Although the exact mechanisms of damage remain unclear, it is essential to better understand these mechanisms to develop methods to diminish ovarian injury.
UR - http://www.scopus.com/inward/record.url?scp=78349260470&partnerID=8YFLogxK
U2 - 10.1097/GRF.0b013e3181f96b54
DO - 10.1097/GRF.0b013e3181f96b54
M3 - Article
VL - 53
SP - 727
EP - 739
JO - Clinical obstetrics and gynecology
JF - Clinical obstetrics and gynecology
SN - 0009-9201
IS - 4
ER -