TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP

Michael X. Zhu, Jianjie Ma, John Parrington, Antony Galione, A. Mark Evans

Research output: Contribution to journalArticlepeer-review

Abstract

Two-pore channels (TPCs or TPCNs) are novel members of the large superfamily of voltage-gated cation channels with slightly higher sequence homology to the pore-forming subunits of voltage-gated Ca2+ and Na+ channels than most other members. Recent studies demonstrate that TPCs locate to endosomes and lysosomes and form Ca2+ release channels that respond to activation by the Ca2+ mobilizing messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). With multiple endolysosomal targeted NAADP receptors now identified, important new insights into the regulation of endolysosomal function in health and disease will therefore be unveiled. (C) 2010 Federation of European Biochemical Societies.
Original languageEnglish
Pages (from-to)1966-1974
Number of pages9
JournalFEBS Letters
Volume584
Issue number10
DOIs
Publication statusPublished - May 2010

Keywords

  • Acidic organelle
  • calcium signaling
  • calcium channel
  • IP3 receptor
  • Ryanodine receptor
  • Bafilomycin

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