Tracing the sources of cellular variation

Sharad Ramanathan, Peter S Swain

Research output: Contribution to journalArticlepeer-review


As the adage says, variety is the spice of life, and despite our best attempts, cells, even those with the same genome, never seem to behave the same. By combining mathematical and experimental analyses, Colman-Lerner and colleagues propose, in a recent issue of Nature, a method to delicately unravel the sources of this variation. Applying their technique to the pheromone response in budding yeast, they show that much of the observed variation originates from cell cycle effects and is dependent on levels of pathway input.
Original languageEnglish
Pages (from-to)576-8
Number of pages3
JournalDevelopmental Cell
Issue number5
Publication statusPublished - 2005


  • Cell Cycle
  • Genetic Variation
  • Pheromones
  • Ribosomes
  • Saccharomyces cerevisiae


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