Traditional Chinese medicine FYTF-919 (Zhongfeng Xingnao oral prescription) for the treatment of acute intracerebral haemorrhage: a multicentre, randomised, placebo-controlled, double-blind, clinical trial

Jianwen Guo; Xiaoying Chen; Manli Wu; Dou Wang; Yang Zhao; Qiang Li; Guanghai Tang; Fengyuan Che; Zhangyong Xia; Zai Liang; Liu Shi; Qiuhua Jiang; Yajie Chen; Xiaoqiu Liu; Xinwen Ren; Menglu Ouyang; Borui Wang; Shoujiang You; Laurent Billot; Xia Wang; Zhenchuan Liu; Hongyan Jing; Wei Meng; Song Tian; Enzhi Liu; Yong Xiang; Xiaoping Tang; Tingting Xie; Wanzhen Cui; Yanwen Zheng; Jiamin Cao; Jingbei Zhang; Zehuai Wen; Tao Huang; Lixin Wang; Chao You; Suyue Pan; Yefeng Cai; Yun Lu; Graeme j Hankey; Rustam Al-Shahi salman; Craig s Anderson; Lili Song; The CHAIN investigators

doi:10.1016/S0140-6736(24)02261-X

Traditional Chinese medicine FYTF-919 (Zhongfeng Xingnao oral prescription) for the treatment of acute intracerebral haemorrhage: a multicentre, randomised, placebo-controlled, double-blind, clinical trial

Jianwen Guo^*, Xiaoying Chen, Manli Wu, Dou Wang, Yang Zhao, Qiang Li, Guanghai Tang, Fengyuan Che, Zhangyong Xia, Zai Liang, Liu Shi, Qiuhua Jiang, Yajie Chen, Xiaoqiu Liu, Xinwen Ren, Menglu Ouyang, Borui Wang, Shoujiang You, Laurent Billot, Xia WangZhenchuan Liu, Hongyan Jing, Wei Meng, Song Tian, Enzhi Liu, Yong Xiang, Xiaoping Tang, Tingting Xie, Wanzhen Cui, Yanwen Zheng, Jiamin Cao, Jingbei Zhang, Zehuai Wen, Tao Huang, Lixin Wang, Chao You, Suyue Pan, Yefeng Cai, Yun Lu, Graeme j Hankey, Rustam Al-Shahi salman, Craig s Anderson^*, Lili Song^*, The CHAIN investigators

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	The Lancet
DOIs	https://doi.org/10.1016/S0140-6736(24)02261-X
Publication status	Published - 1 Nov 2024

Access to Document

10.1016/S0140-6736(24)02261-X

CHAIN_main results_revision_Final_cleanAccepted author manuscript, 287 KBLicence: Creative Commons: Attribution (CC-BY)

https://linkinghub.elsevier.com/retrieve/pii/S014067362402261X

Cite this

Guo, J., Chen, X., Wu, M., Wang, D., Zhao, Y., Li, Q., Tang, G., Che, F., Xia, Z., Liang, Z., Shi, L., Jiang, Q., Chen, Y., Liu, X., Ren, X., Ouyang, M., Wang, B., You, S., Billot, L., ... The CHAIN investigators (2024). Traditional Chinese medicine FYTF-919 (Zhongfeng Xingnao oral prescription) for the treatment of acute intracerebral haemorrhage: a multicentre, randomised, placebo-controlled, double-blind, clinical trial. The Lancet. https://doi.org/10.1016/S0140-6736(24)02261-X

@article{509070129c3c4bb4be4c8676cc29758e,

title = "Traditional Chinese medicine FYTF-919 (Zhongfeng Xingnao oral prescription) for the treatment of acute intracerebral haemorrhage: a multicentre, randomised, placebo-controlled, double-blind, clinical trial",

author = "Jianwen Guo and Xiaoying Chen and Manli Wu and Dou Wang and Yang Zhao and Qiang Li and Guanghai Tang and Fengyuan Che and Zhangyong Xia and Zai Liang and Liu Shi and Qiuhua Jiang and Yajie Chen and Xiaoqiu Liu and Xinwen Ren and Menglu Ouyang and Borui Wang and Shoujiang You and Laurent Billot and Xia Wang and Zhenchuan Liu and Hongyan Jing and Wei Meng and Song Tian and Enzhi Liu and Yong Xiang and Xiaoping Tang and Tingting Xie and Wanzhen Cui and Yanwen Zheng and Jiamin Cao and Jingbei Zhang and Zehuai Wen and Tao Huang and Lixin Wang and Chao You and Suyue Pan and Yefeng Cai and Yun Lu and Hankey, {Graeme j} and {Al-Shahi salman}, Rustam and Anderson, {Craig s} and Lili Song and {The CHAIN investigators} and Anderson, {Craig s} and Lili Song and Jianwen Guo and Yefeng Cai and Yang Zhao and Xiaoying Chen and Chao You and Suyue Pan and Guanghai Tang and Yun Lu and Hankey, {Graeme j} and {Al-Shahi salman}, Rustam and Jiguang Wang and Bruce Campbell and Chris Chen and Rong Hu and Qiang Li and Xian Li and Yingfeng Wan and Shoujiang You and Congcong Zhang and Zhong Gui and Man Chen and Shuman Ouyang and Xin Zhao and Chengju Huo and Ru Ban and Jingru Wang and Yajie Chen and Lilan Zhang and Wenjing Yu and Borui Wang and Le Dong and Yi Ning and Penggang Li and Manli Wu and Dou Wang and Yanwen Zheng and Fengyan Huang and Zhixuan Ren and Jingbei Zhang and Zhihua Zheng and Kunhong Li and Xinwei Wang and Yongqi Li and Jiamin Cao and Lili Song and Huaying Zhu and Xinning Tan and Xinhong Qiu and Zhongkang Yang and Zhenzhen Lou and Tingting Xie and Haining Zhao and Yu Tang and Dafeng Hu and Wanzhen Cui and Mingjiang Xie and Daxiu Wang and Xiaoshu Wu and Yingyi Zheng and Rui Mao and Hao Chen and Min Luo and Suqin Xue and Chunji Li and Jiekai Chen and Hongtao Jiang and Hongyan Jing and Xu Zhang and Yingnan Xu and Haiguang Yan and Guang Yang and Feilong Wang and Xiaodi Lu and Li Yan and Fengyuan Che and Zhenchuan Liu and Zhongxiang Xie and Feng He and Wanqi Liu and Ruixue Zhuang and Qi Su and Xuli Zhang and Zhangyong Xia and Guangjun Xu and Tuanzhi Chen and Zai Liang and Qingyan Jiang and Guanli Su and Liufu Xiao and Xiaoying Zhang and Liu Shi and Wei Zheng and Yongjian Zhang and Jiao Chen and Xiang Yin and Qiuhua Jiang and Zhenyu Zhang and Jinqing Huang and Qianliang Huang and Honghua Guo and Wei Meng and Bin Zhang and Yulin Zhang and Chun Dong and Jie Shi and Song Tian and Xiong Deng and Zhijun Liang and Haixiang Zhong and Chubao Liu and Xiaoguang Shao and Enzhi Liu and Weiqi Fu and Wei Sheng and Minghui Chen and Yong Xiang and Yanping Chen and Teng Long and Jie Zhang and Tinghao Chang and Xiaoping Tang and Long Zhao and Junde Wu and Yangjingtian Hu and Zheng Li and Rutong Yu and Lei Hua and Yong Wang and Yanhong Ren and Haibo Zhang and Jun Tang and Jianzhong Shu and Chao Luo and Gaung Wang and Yueyue Guan and Yue Wan and Shangsheng Ke and Dandan He and Zhenyi Wang and Chenghang Lu and Xie Li and Jianbin Zhong and Simin Zhong and Yanfang Lai and Shijun Zhang and Lixin Wang and Guifu Li and Lijin Huang and Jinsong You and Tao Huang and Zheng Zhen and Daojin Xue and Guo Ke and Qiurong He and Li Lei and Tie Guo and Hui Li and Yunxue Pu and Hailin Zhu and Gang Yang and Maohua Zheng and Wei Hou and Yue Yu and Haijun Yang and Gang He and Yuan Ran and Xiaoli Fan and Lai Xu and Shihui Zou and Xiaoxin Bai and Jun Cai and Ruicong Chen and Yinbin Li and Huai Tu and Guohua Ren and Jiye Zhao and Yunna Wang and Jianhui Shi and Yafeng Bai and Lin Lin and Dazhi Li and Ning Cai and Yonghui Zhang and Xiaochen Yu and Zonghua Jiang and Cong Wang and Dehai He and Jiahe Lai and Xujuan Yuan and Zeshun Zhang and Minqing Zhao and Defang Qin and Yonglin Huo and Bangxiang Wang and Shaohong Chen and Xu Jiao and Mingfei Li",

year = "2024",

month = nov,

day = "1",

doi = "10.1016/S0140-6736(24)02261-X",

language = "English",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier",

}

Guo, J, Chen, X, Wu, M, Wang, D, Zhao, Y, Li, Q, Tang, G, Che, F, Xia, Z, Liang, Z, Shi, L, Jiang, Q, Chen, Y, Liu, X, Ren, X, Ouyang, M, Wang, B, You, S, Billot, L, Wang, X, Liu, Z, Jing, H, Meng, W, Tian, S, Liu, E, Xiang, Y, Tang, X, Xie, T, Cui, W, Zheng, Y, Cao, J, Zhang, J, Wen, Z, Huang, T, Wang, L, You, C, Pan, S, Cai, Y, Lu, Y, Hankey, GJ, Al-Shahi salman, R, Anderson, CS, Song, L & The CHAIN investigators 2024, 'Traditional Chinese medicine FYTF-919 (Zhongfeng Xingnao oral prescription) for the treatment of acute intracerebral haemorrhage: a multicentre, randomised, placebo-controlled, double-blind, clinical trial', The Lancet. https://doi.org/10.1016/S0140-6736(24)02261-X

TY - JOUR

T1 - Traditional Chinese medicine FYTF-919 (Zhongfeng Xingnao oral prescription) for the treatment of acute intracerebral haemorrhage: a multicentre, randomised, placebo-controlled, double-blind, clinical trial

AU - Guo, Jianwen

AU - Chen, Xiaoying

AU - Wu, Manli

AU - Wang, Dou

AU - Zhao, Yang

AU - Li, Qiang

AU - Tang, Guanghai

AU - Che, Fengyuan

AU - Xia, Zhangyong

AU - Liang, Zai

AU - Shi, Liu

AU - Jiang, Qiuhua

AU - Chen, Yajie

AU - Liu, Xiaoqiu

AU - Ren, Xinwen

AU - Ouyang, Menglu

AU - Wang, Borui

AU - You, Shoujiang

AU - Billot, Laurent

AU - Wang, Xia

AU - Liu, Zhenchuan

AU - Jing, Hongyan

AU - Meng, Wei

AU - Tian, Song

AU - Liu, Enzhi

AU - Xiang, Yong

AU - Tang, Xiaoping

AU - Xie, Tingting

AU - Cui, Wanzhen

AU - Zheng, Yanwen

AU - Cao, Jiamin

AU - Zhang, Jingbei

AU - Wen, Zehuai

AU - Huang, Tao

AU - Wang, Lixin

AU - You, Chao

AU - Pan, Suyue

AU - Cai, Yefeng

AU - Lu, Yun

AU - Hankey, Graeme j

AU - Al-Shahi salman, Rustam

AU - Anderson, Craig s

AU - Song, Lili

AU - The CHAIN investigators

AU - Anderson, Craig s

AU - Song, Lili

AU - Guo, Jianwen

AU - Cai, Yefeng

AU - Zhao, Yang

AU - Chen, Xiaoying

AU - You, Chao

AU - Pan, Suyue

AU - Tang, Guanghai

AU - Lu, Yun

AU - Hankey, Graeme j

AU - Al-Shahi salman, Rustam

AU - Wang, Jiguang

AU - Campbell, Bruce

AU - Chen, Chris

AU - Hu, Rong

AU - Li, Qiang

AU - Li, Xian

AU - Wan, Yingfeng

AU - You, Shoujiang

AU - Zhang, Congcong

AU - Gui, Zhong

AU - Chen, Man

AU - Ouyang, Shuman

AU - Zhao, Xin

AU - Huo, Chengju

AU - Ban, Ru

AU - Wang, Jingru

AU - Chen, Yajie

AU - Zhang, Lilan

AU - Yu, Wenjing

AU - Wang, Borui

AU - Dong, Le

AU - Ning, Yi

AU - Li, Penggang

AU - Wu, Manli

AU - Wang, Dou

AU - Zheng, Yanwen

AU - Huang, Fengyan

AU - Ren, Zhixuan

AU - Zhang, Jingbei

AU - Zheng, Zhihua

AU - Li, Kunhong

AU - Wang, Xinwei

AU - Li, Yongqi

AU - Cao, Jiamin

AU - Song, Lili

AU - Zhu, Huaying

AU - Tan, Xinning

AU - Qiu, Xinhong

AU - Yang, Zhongkang

AU - Lou, Zhenzhen

AU - Xie, Tingting

AU - Zhao, Haining

AU - Tang, Yu

AU - Hu, Dafeng

AU - Cui, Wanzhen

AU - Xie, Mingjiang

AU - Wang, Daxiu

AU - Wu, Xiaoshu

AU - Zheng, Yingyi

AU - Mao, Rui

AU - Chen, Hao

AU - Luo, Min

AU - Xue, Suqin

AU - Li, Chunji

AU - Chen, Jiekai

AU - Jiang, Hongtao

AU - Jing, Hongyan

AU - Zhang, Xu

AU - Xu, Yingnan

AU - Yan, Haiguang

AU - Yang, Guang

AU - Wang, Feilong

AU - Lu, Xiaodi

AU - Yan, Li

AU - Che, Fengyuan

AU - Liu, Zhenchuan

AU - Xie, Zhongxiang

AU - He, Feng

AU - Liu, Wanqi

AU - Zhuang, Ruixue

AU - Su, Qi

AU - Zhang, Xuli

AU - Xia, Zhangyong

AU - Xu, Guangjun

AU - Chen, Tuanzhi

AU - Liang, Zai

AU - Jiang, Qingyan

AU - Su, Guanli

AU - Xiao, Liufu

AU - Zhang, Xiaoying

AU - Shi, Liu

AU - Zheng, Wei

AU - Zhang, Yongjian

AU - Chen, Jiao

AU - Yin, Xiang

AU - Jiang, Qiuhua

AU - Zhang, Zhenyu

AU - Huang, Jinqing

AU - Huang, Qianliang

AU - Guo, Honghua

AU - Meng, Wei

AU - Zhang, Bin

AU - Zhang, Yulin

AU - Dong, Chun

AU - Shi, Jie

AU - Tian, Song

AU - Deng, Xiong

AU - Liang, Zhijun

AU - Zhong, Haixiang

AU - Liu, Chubao

AU - Shao, Xiaoguang

AU - Liu, Enzhi

AU - Fu, Weiqi

AU - Sheng, Wei

AU - Chen, Minghui

AU - Xiang, Yong

AU - Chen, Yanping

AU - Long, Teng

AU - Zhang, Jie

AU - Chang, Tinghao

AU - Tang, Xiaoping

AU - Zhao, Long

AU - Wu, Junde

AU - Hu, Yangjingtian

AU - Li, Zheng

AU - Yu, Rutong

AU - Hua, Lei

AU - Wang, Yong

AU - Ren, Yanhong

AU - Zhang, Haibo

AU - Tang, Jun

AU - Shu, Jianzhong

AU - Luo, Chao

AU - Wang, Gaung

AU - Guan, Yueyue

AU - Wan, Yue

AU - Ke, Shangsheng

AU - He, Dandan

AU - Wang, Zhenyi

AU - Lu, Chenghang

AU - Li, Xie

AU - Zhong, Jianbin

AU - Zhong, Simin

AU - Lai, Yanfang

AU - Zhang, Shijun

AU - Wang, Lixin

AU - Li, Guifu

AU - Huang, Lijin

AU - You, Jinsong

AU - Huang, Tao

AU - Zhen, Zheng

AU - Xue, Daojin

AU - Ke, Guo

AU - He, Qiurong

AU - Lei, Li

AU - Guo, Tie

AU - Li, Hui

AU - Pu, Yunxue

AU - Zhu, Hailin

AU - Yang, Gang

AU - Zheng, Maohua

AU - Hou, Wei

AU - Yu, Yue

AU - Yang, Haijun

AU - He, Gang

AU - Ran, Yuan

AU - Fan, Xiaoli

AU - Xu, Lai

AU - Zou, Shihui

AU - Bai, Xiaoxin

AU - Cai, Jun

AU - Chen, Ruicong

AU - Li, Yinbin

AU - Tu, Huai

AU - Ren, Guohua

AU - Zhao, Jiye

AU - Wang, Yunna

AU - Shi, Jianhui

AU - Bai, Yafeng

AU - Lin, Lin

AU - Li, Dazhi

AU - Cai, Ning

AU - Zhang, Yonghui

AU - Yu, Xiaochen

AU - Jiang, Zonghua

AU - Wang, Cong

AU - He, Dehai

AU - Lai, Jiahe

AU - Yuan, Xujuan

AU - Zhang, Zeshun

AU - Zhao, Minqing

AU - Qin, Defang

AU - Huo, Yonglin

AU - Wang, Bangxiang

AU - Chen, Shaohong

AU - Jiao, Xu

AU - Li, Mingfei

PY - 2024/11/1

Y1 - 2024/11/1

U2 - 10.1016/S0140-6736(24)02261-X

DO - 10.1016/S0140-6736(24)02261-X

M3 - Article

SN - 0140-6736

JO - The Lancet

JF - The Lancet

ER -

Traditional Chinese medicine FYTF-919 (Zhongfeng Xingnao oral prescription) for the treatment of acute intracerebral haemorrhage: a multicentre, randomised, placebo-controlled, double-blind, clinical trial

Access to Document

Other files and links

Cite this