TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?

Eitan Winter, Chris P Ponting

Research output: Contribution to journalArticlepeer-review


A family of membrane-associated proteins related to yeast Lag1p and mammalian TRAM has been identified. The family includes the protein product of CLN8, a gene mutated in progressive epilepsy with mental retardation. Mouse CLN8 is also mutated in the mnd/mnd mouse, a model for neuronal ceroid lipofuscinoses. The identification of these homologues has potential implications for our understanding of ceramide synthesis, lipid regulation and protein translocation in the endoplasmic reticulum.

Original languageEnglish
Pages (from-to)381-3
Number of pages3
JournalTrends in biochemical sciences
Issue number8
Publication statusPublished - Aug 2002


  • Amino Acid Sequence
  • Animals
  • Fungal Proteins
  • Humans
  • Lipid Metabolism
  • Membrane Glycoproteins
  • Membrane Proteins
  • Membrane Transport Proteins
  • Mice
  • Molecular Sequence Data
  • Mutation
  • Protein Structure, Tertiary
  • Saccharomyces cerevisiae Proteins
  • Sequence Homology, Amino Acid


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