TRANSCRIPTION FACTOR AP-2 GENE-EXPRESSION IN ADULT-RAT HIPPOCAMPAL REGIONS - EFFECTS OF ENVIRONMENTAL MANIPULATIONS

T  OLSSON; A K  MOHAMMED; L F  DONALDSON; J R  SECKL

TRANSCRIPTION FACTOR AP-2 GENE-EXPRESSION IN ADULT-RAT HIPPOCAMPAL REGIONS - EFFECTS OF ENVIRONMENTAL MANIPULATIONS

T OLSSON, A K MOHAMMED, L F DONALDSON, J R SECKL

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Environmental enrichment increases glucocorticoid receptor expression in hippocampal pyramidal neurons, but the molecular mechanisms are unknown. Several transcription factors are expressed in hippocampal neurons where they respond to environmental stimuli. In this study 12 adult male rats (n = 6 in each group) were exposed to enriched or isolated environment for 30 days. The expression of AP-2 mRNA, studied by in situ hybridization, was attenuated by environmental enrichment in the CA2 and CA3 subfields of the hippocampus. AP-2 may be involved in the environmental effect of glucocorticoid receptor gene expression in these neurons.

Original language	English
Pages (from-to)	113-116
Number of pages	4
Journal	Neuroscience Letters
Volume	189
Issue number	2
Publication status	Published - 14 Apr 1995

Cite this

@article{11007c560ec24847982128d32127d01d,

title = "TRANSCRIPTION FACTOR AP-2 GENE-EXPRESSION IN ADULT-RAT HIPPOCAMPAL REGIONS - EFFECTS OF ENVIRONMENTAL MANIPULATIONS",

abstract = "Environmental enrichment increases glucocorticoid receptor expression in hippocampal pyramidal neurons, but the molecular mechanisms are unknown. Several transcription factors are expressed in hippocampal neurons where they respond to environmental stimuli. In this study 12 adult male rats (n = 6 in each group) were exposed to enriched or isolated environment for 30 days. The expression of AP-2 mRNA, studied by in situ hybridization, was attenuated by environmental enrichment in the CA2 and CA3 subfields of the hippocampus. AP-2 may be involved in the environmental effect of glucocorticoid receptor gene expression in these neurons.",

author = "T OLSSON and MOHAMMED, {A K} and DONALDSON, {L F} and SECKL, {J R}",

year = "1995",

month = apr,

day = "14",

language = "English",

volume = "189",

pages = "113--116",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - TRANSCRIPTION FACTOR AP-2 GENE-EXPRESSION IN ADULT-RAT HIPPOCAMPAL REGIONS - EFFECTS OF ENVIRONMENTAL MANIPULATIONS

AU - OLSSON, T

AU - MOHAMMED, A K

AU - DONALDSON, L F

AU - SECKL, J R

PY - 1995/4/14

Y1 - 1995/4/14

N2 - Environmental enrichment increases glucocorticoid receptor expression in hippocampal pyramidal neurons, but the molecular mechanisms are unknown. Several transcription factors are expressed in hippocampal neurons where they respond to environmental stimuli. In this study 12 adult male rats (n = 6 in each group) were exposed to enriched or isolated environment for 30 days. The expression of AP-2 mRNA, studied by in situ hybridization, was attenuated by environmental enrichment in the CA2 and CA3 subfields of the hippocampus. AP-2 may be involved in the environmental effect of glucocorticoid receptor gene expression in these neurons.

AB - Environmental enrichment increases glucocorticoid receptor expression in hippocampal pyramidal neurons, but the molecular mechanisms are unknown. Several transcription factors are expressed in hippocampal neurons where they respond to environmental stimuli. In this study 12 adult male rats (n = 6 in each group) were exposed to enriched or isolated environment for 30 days. The expression of AP-2 mRNA, studied by in situ hybridization, was attenuated by environmental enrichment in the CA2 and CA3 subfields of the hippocampus. AP-2 may be involved in the environmental effect of glucocorticoid receptor gene expression in these neurons.

M3 - Article

VL - 189

SP - 113

EP - 116

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -

TRANSCRIPTION FACTOR AP-2 GENE-EXPRESSION IN ADULT-RAT HIPPOCAMPAL REGIONS - EFFECTS OF ENVIRONMENTAL MANIPULATIONS

Abstract

Fingerprint

Cite this