Transcriptional regulation by complex interplay between posttranslational modifications

Michael J Skelly, Lucas Frungillo, Steven H Spoel

Research output: Contribution to journalArticlepeer-review


Transcriptional reprogramming in response to developmental changes or environmental inputs is regulated by a wide variety of transcription factors and cofactors. In plants, the stability of many transcriptional regulators is mediated by the ubiquitin-mediated proteasome. Recent reports suggest that additional post-translational modifications modulate the ubiquitination and thus stability of transcriptional regulators. In addition to well-recognized phosphorylative control, particularly conjugation to the ubiquitin-like protein SUMO as well as thiol modification by nitric oxide to yield S-nitrosothiols, are emerging as key regulatory steps for governing protein ubiquitination in the nucleus. Complex interplay between these different post-translational modifications may provide robust control mechanisms to fine tune developmental and stress-responsive transcriptional programs.

Original languageEnglish
Pages (from-to)126-132
Number of pages7
JournalCurrent opinion in plant biology
Early online date20 Jul 2016
Publication statusPublished - Oct 2016


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