Transcriptional regulators of arteriovenous identity in the developing mammalian embryo

Ian McCracken, Andrew H Baker, Nicola Smart, Sarah De val

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

The complex and hierarchical vascular network of arteries, veins, and capillaries features considerable endothelial heterogeneity, yet the regulatory pathways directing arteriovenous specification, differentiation and identity are still not fully understood. Recent advances in analysis of endothelial-specific gene regulatory elements, single cell RNA sequencing (scRNA-seq) and cell lineage tracing has both emphasized the importance of transcriptional regulation in this process and shed considerable light on the mechanism and regulation of specification within the endothelium. In this review we discuss recent advances in our understanding of how endothelial cells acquire arterial and venous identity and the role different transcription factors play in this process.
Original languageEnglish
JournalCurrent opinion in physiology
Early online date28 Jun 2023
DOIs
Publication statusE-pub ahead of print - 28 Jun 2023

Keywords / Materials (for Non-textual outputs)

  • Endothelial cell
  • transcriptional regulation
  • transcription factors
  • vasculature
  • endothelium
  • artery
  • arterial regulation
  • vein
  • venous regulation
  • arterialization
  • arteriogenesis

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